Monitoring drug delivery processes by EPR and related techniques – principles and applications

David John Lurie, K. Maeder

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Electron Paramagnetic Resonance (EPR, or ESR) is a powerful non-invasive spectroscopic tool that can be used to monitor drug release processes in vitro and in vivo. Furthermore, spatial dissolution can be achieved by means of EPR-Imaging. The article introduces the basics of EPR and EPR-imaging. It discusses also the challenges of in vivo spectroscopy and imaging and presents information about new developments such as longitudinally detected EPR (LODEPR) and Proton Electron Double Resonance Imaging ((PEDRI). Examples of the usefulness of EPR in the field of drug delivery include the measurement of microviscosity and micropolarity, the direct detection of drug release mechanisms in vitro and in vivo, the monitoring of microacidity in biodegradable polymers and the characterisation of colloidal drug carriers. (c) 2005 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)1171-1190
Number of pages19
JournalAdvanced Drug Delivery Reviews
Volume57
DOIs
Publication statusPublished - 2005

Keywords

  • ESR
  • EPR
  • drug delivery
  • PEDRI
  • overhauser imaging
  • EPR imaging
  • in vivo EPR
  • ELECTRON-PARAMAGNETIC-RESONANCE
  • NUCLEAR-MAGNETIC-RESONANCE
  • SOLID LIPID NANOPARTICLES
  • FIELD-CYCLED PEDRI
  • IN-VIVO EPR
  • SPIN-RESONANCE
  • HYDROXYPROPYL METHYLCELLULOSE
  • POLY(ORTHO ESTER)
  • POLYMER EROSION
  • FREE-RADICALS

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