Mortality from cerebrovascular disease in a cohort of 23,000 patients with insulin-treated diabetes

S. P. Laing, A. J. Swerdlow, L. M. Carpenter, S. D. Slater, A. C. Burden, J. L. Botha, A. D. Morris, Norman Robert Waugh

Research output: Contribution to journalArticle

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Abstract

Background and Purpose-Disease of the cardiovascular system is the main cause of long-term complications and mortality in patients with type I (insulin-dependent) and type 11 (non-insulin-dependent) diabetes. Cerebrovascular mortality rates have been shown to be raised in patients with type 11 diabetes but have not previously been reported by age and sex in patients with type I diabetes.

Methods-A cohort of 23 751 patients with insulin-treated diabetes, diagnosed under the age of 30 years from throughout the United Kingdom, was identified during 1972 to 1993 and followed up for mortality until the end. of December 2000. Age- and sex-specific mortality rates and standardized mortality ratios (SMRs) were calculated.

Results-There were 1437 deaths during the follow-up, 80 due to cerebrovascular disease. Overall, the cerebrovascular mortality rates in the cohort were higher than the corresponding rates in the general population, and the SMRs were 3.1 (95% Cl, 2.2 to 4.3) for men and 4.4 (95% Cl, 3.1 to 6.0) for women. When stratified by age, the SMRs were highest in the 20- to 39-year age group. After subdivision of cause of death into hemorrhagic and nonhemorrhagic origins, there remained a significant increase in mortality from stroke of nonhemorrhagic origin.

Conclusions-Analyses of mortality from this cohort, essentially one of patients with type I diabetes, has shown for the first time that cerebrovascular mortality is raised at all ages in these patients. Type I diabetes is at least as great a risk factor for cerebrovascular mortality as type II diabetes.

Original languageEnglish
Pages (from-to)418-421
Number of pages3
JournalStroke
Volume34
DOIs
Publication statusPublished - 2003

Keywords

  • cerebrovascular disease
  • cohort study
  • type I diabetes mellitus
  • CARDIOVASCULAR MORTALITY
  • ASSOCIATION COHORT
  • VASCULAR-DISEASE
  • MELLITUS
  • STROKE
  • ONSET
  • RISK
  • MORBIDITY
  • AGE

Cite this

Laing, S. P., Swerdlow, A. J., Carpenter, L. M., Slater, S. D., Burden, A. C., Botha, J. L., ... Waugh, N. R. (2003). Mortality from cerebrovascular disease in a cohort of 23,000 patients with insulin-treated diabetes. Stroke, 34, 418-421. https://doi.org/10.1161/01.STR.0000053843.03997.35

Mortality from cerebrovascular disease in a cohort of 23,000 patients with insulin-treated diabetes. / Laing, S. P.; Swerdlow, A. J.; Carpenter, L. M.; Slater, S. D.; Burden, A. C.; Botha, J. L.; Morris, A. D.; Waugh, Norman Robert.

In: Stroke, Vol. 34, 2003, p. 418-421.

Research output: Contribution to journalArticle

Laing, SP, Swerdlow, AJ, Carpenter, LM, Slater, SD, Burden, AC, Botha, JL, Morris, AD & Waugh, NR 2003, 'Mortality from cerebrovascular disease in a cohort of 23,000 patients with insulin-treated diabetes', Stroke, vol. 34, pp. 418-421. https://doi.org/10.1161/01.STR.0000053843.03997.35
Laing, S. P. ; Swerdlow, A. J. ; Carpenter, L. M. ; Slater, S. D. ; Burden, A. C. ; Botha, J. L. ; Morris, A. D. ; Waugh, Norman Robert. / Mortality from cerebrovascular disease in a cohort of 23,000 patients with insulin-treated diabetes. In: Stroke. 2003 ; Vol. 34. pp. 418-421.
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T1 - Mortality from cerebrovascular disease in a cohort of 23,000 patients with insulin-treated diabetes

AU - Laing, S. P.

AU - Swerdlow, A. J.

AU - Carpenter, L. M.

AU - Slater, S. D.

AU - Burden, A. C.

AU - Botha, J. L.

AU - Morris, A. D.

AU - Waugh, Norman Robert

PY - 2003

Y1 - 2003

N2 - Background and Purpose-Disease of the cardiovascular system is the main cause of long-term complications and mortality in patients with type I (insulin-dependent) and type 11 (non-insulin-dependent) diabetes. Cerebrovascular mortality rates have been shown to be raised in patients with type 11 diabetes but have not previously been reported by age and sex in patients with type I diabetes.Methods-A cohort of 23 751 patients with insulin-treated diabetes, diagnosed under the age of 30 years from throughout the United Kingdom, was identified during 1972 to 1993 and followed up for mortality until the end. of December 2000. Age- and sex-specific mortality rates and standardized mortality ratios (SMRs) were calculated.Results-There were 1437 deaths during the follow-up, 80 due to cerebrovascular disease. Overall, the cerebrovascular mortality rates in the cohort were higher than the corresponding rates in the general population, and the SMRs were 3.1 (95% Cl, 2.2 to 4.3) for men and 4.4 (95% Cl, 3.1 to 6.0) for women. When stratified by age, the SMRs were highest in the 20- to 39-year age group. After subdivision of cause of death into hemorrhagic and nonhemorrhagic origins, there remained a significant increase in mortality from stroke of nonhemorrhagic origin.Conclusions-Analyses of mortality from this cohort, essentially one of patients with type I diabetes, has shown for the first time that cerebrovascular mortality is raised at all ages in these patients. Type I diabetes is at least as great a risk factor for cerebrovascular mortality as type II diabetes.

AB - Background and Purpose-Disease of the cardiovascular system is the main cause of long-term complications and mortality in patients with type I (insulin-dependent) and type 11 (non-insulin-dependent) diabetes. Cerebrovascular mortality rates have been shown to be raised in patients with type 11 diabetes but have not previously been reported by age and sex in patients with type I diabetes.Methods-A cohort of 23 751 patients with insulin-treated diabetes, diagnosed under the age of 30 years from throughout the United Kingdom, was identified during 1972 to 1993 and followed up for mortality until the end. of December 2000. Age- and sex-specific mortality rates and standardized mortality ratios (SMRs) were calculated.Results-There were 1437 deaths during the follow-up, 80 due to cerebrovascular disease. Overall, the cerebrovascular mortality rates in the cohort were higher than the corresponding rates in the general population, and the SMRs were 3.1 (95% Cl, 2.2 to 4.3) for men and 4.4 (95% Cl, 3.1 to 6.0) for women. When stratified by age, the SMRs were highest in the 20- to 39-year age group. After subdivision of cause of death into hemorrhagic and nonhemorrhagic origins, there remained a significant increase in mortality from stroke of nonhemorrhagic origin.Conclusions-Analyses of mortality from this cohort, essentially one of patients with type I diabetes, has shown for the first time that cerebrovascular mortality is raised at all ages in these patients. Type I diabetes is at least as great a risk factor for cerebrovascular mortality as type II diabetes.

KW - cerebrovascular disease

KW - cohort study

KW - type I diabetes mellitus

KW - CARDIOVASCULAR MORTALITY

KW - ASSOCIATION COHORT

KW - VASCULAR-DISEASE

KW - MELLITUS

KW - STROKE

KW - ONSET

KW - RISK

KW - MORBIDITY

KW - AGE

U2 - 10.1161/01.STR.0000053843.03997.35

DO - 10.1161/01.STR.0000053843.03997.35

M3 - Article

VL - 34

SP - 418

EP - 421

JO - Stroke

JF - Stroke

SN - 0039-2499

ER -