Mouse Model of Invasive Fungal Infection

Donna M. MacCallum*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

The mouse intravenous (IV) challenge model of Candida albicans invasive fungal infection has been widely used to study the importance of the innate immune system in these infections. This chapter describes this well-characterized model, where fungal cells are administered directly into the mouse bloodstream to initiate a systemic infection. The preparation of tissue samples from infected mice to allow evaluation of disease progression and host responses is also described.

Original languageEnglish
Title of host publicationMouse Models of Innate Immunity
Subtitle of host publicationMethods and Protocols
EditorsIrving C. Allen
Place of PublicationTotowa
PublisherHumana Press
Pages145-153
Number of pages9
ISBN (Electronic)9781627034814
ISBN (Print)9781627034807
DOIs
Publication statusPublished - 2013

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
Volume1031
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

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Keywords

  • Candida albicans
  • Immunity
  • Infection
  • Intravenous
  • Organ-specific
  • Virulence

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

MacCallum, D. M. (2013). Mouse Model of Invasive Fungal Infection. In I. C. Allen (Ed.), Mouse Models of Innate Immunity: Methods and Protocols (pp. 145-153). [17] (Methods in Molecular Biology; Vol. 1031). Totowa: Humana Press. https://doi.org/10.1007/978-1-62703-481-4_17