TY - JOUR
T1 - mRNA translation and turnover
T2 - a cellular perspective on their relationship
AU - Brown, Alistair J.P.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - The rate at which a protein is synthesized is influenced by the stability of its mRNA and the efficiency of translation. mRNA degradation is associated with translation, but the link between these processes is unclear. In this article, Alistair Brown discusses this relationship in the light of a model of translation that involves three distinct cellular phases: a primary phase in which the translation of an mRNA molecule starts before its export from the nucleus is complete, a secondary phase that begins when nuclear export is complete and that may involve circular polyribosomal complexes, and a terminal phase involving residual translation once mRNA degradation is initiated.
AB - The rate at which a protein is synthesized is influenced by the stability of its mRNA and the efficiency of translation. mRNA degradation is associated with translation, but the link between these processes is unclear. In this article, Alistair Brown discusses this relationship in the light of a model of translation that involves three distinct cellular phases: a primary phase in which the translation of an mRNA molecule starts before its export from the nucleus is complete, a secondary phase that begins when nuclear export is complete and that may involve circular polyribosomal complexes, and a terminal phase involving residual translation once mRNA degradation is initiated.
UR - http://www.scopus.com/inward/record.url?scp=0027315968&partnerID=8YFLogxK
U2 - 10.1016/0962-8924(93)90206-G
DO - 10.1016/0962-8924(93)90206-G
M3 - Article
AN - SCOPUS:0027315968
VL - 3
SP - 180
EP - 183
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 6
ER -