MS-based Methodologies to Study the Microbial Metabolome

Wendy R. Russell*, Sylvia H. Duncan

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Emerging evidence suggests that the gut microbiota plays an important role in the development of many diseases including diabetes, cardiovascular disease, and cancer. There have been tremendous advances in characterizing the microbial diversity within the gastrointestinal tract, but very little is known about their function and role within the human host. It is becoming widely accepted that the metabolic products produced by the gut bacteria are a major factor influencing human health and disease. However, in most cases, the products of metabolism are uncharacterized. Mass spectroscopic-based methodologies provide a vital tool for the characterization of these gut metabolites, and this chapter explores the use of this technique to evaluate the microbial metabolome.

Original languageEnglish
Title of host publicationFoodomics
Subtitle of host publicationAdvanced Mass Spectrometry in Modern Food Science and Nutrition
EditorsAlejandro Cifuentes
PublisherJohn Wiley & Sons Ltd.
Number of pages23
ISBN (Electronic)9781118537282
ISBN (Print)9781118169452
Publication statusPublished - 4 Mar 2013


  • Gut health
  • Metabolomics
  • Metagenomics
  • Microbial metabolites


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