Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies novel loci associated with serum lipids

COGENT-Kidney Consortium, Amy R Bentley (Corresponding Author), Yun J Sung, Michael R Brown, Thomas W Winkler, Aldi T Kraja, Ioanna Ntalla, Karen Schwander, Daniel I Chasman, Elise Lim, Xuan Deng, Xiuqing Guo, Jingmin Liu, Yingchang Lu, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jennifer E Huffman, Solomon K Musani, Changwei Li & 31 others Mary F Feitosa, Melissa A Richard, Raymond Noordam, Jenna Baker, Guanjie Chen, Hugues Aschard, Traci M Bartz, Jingzhong Ding, Rajkumar Dorajoo, Alisa K Manning, Tuomo Rankinen, Albert V Smith, Salman M Tajuddin, Wei Zhao, Mariaelisa Graff, Maris Alver, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Evangelos Evangelou, Chuan Gao, Anuj Goel, Yanick Hagemeijer, Sarah E Harris, Fernando P Hartwig, Meian He, Andrea R V R Horimoto, Fang-Chi Hsu, Yi-Jen Hung, Alison D Murray

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The concentrations of high- and low-density lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 novel loci, some of which were detected only because the association differed by smoking status. Additionally, we demonstrated the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
Original languageEnglish
Pages (from-to)636-648
Number of pages13
JournalNature Genetics
Volume51
Issue number4
Early online date29 Mar 2019
DOIs
Publication statusPublished - Apr 2019

Fingerprint

Smoking
Genome
Lipids
Serum
Genes
Life Style
LDL Cholesterol
Meta-Analysis
Population

Keywords

  • cardiovascular diseases
  • genome wide association studies
  • genomics
  • ENVIRONMENT INTERACTION
  • METAANALYSIS
  • CHOLESTEROL
  • CIGARETTES
  • VARIANTS
  • SUSCEPTIBILITY
  • NICOTINE METABOLISM
  • RISK LOCI
  • GENOTYPE IMPUTATION
  • ARCHITECTURE

ASJC Scopus subject areas

  • Genetics

Cite this

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies novel loci associated with serum lipids. / COGENT-Kidney Consortium; Bentley, Amy R (Corresponding Author); Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F; Richard, Melissa A; Noordam, Raymond; Baker, Jenna; Chen, Guanjie; Aschard, Hugues; Bartz, Traci M; Ding, Jingzhong; Dorajoo, Rajkumar; Manning, Alisa K; Rankinen, Tuomo; Smith, Albert V; Tajuddin, Salman M; Zhao, Wei; Graff, Mariaelisa; Alver, Maris; Boissel, Mathilde; Chai, Jin Fang; Chen, Xu; Divers, Jasmin; Evangelou, Evangelos; Gao, Chuan; Goel, Anuj; Hagemeijer, Yanick; Harris, Sarah E; Hartwig, Fernando P; He, Meian; Horimoto, Andrea R V R; Hsu, Fang-Chi; Hung, Yi-Jen; Murray, Alison D.

In: Nature Genetics, Vol. 51, No. 4, 04.2019, p. 636-648.

Research output: Contribution to journalArticle

COGENT-Kidney Consortium, Bentley, AR, Sung, YJ, Brown, MR, Winkler, TW, Kraja, AT, Ntalla, I, Schwander, K, Chasman, DI, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, C-Y, Sim, X, Vojinovic, D, Huffman, JE, Musani, SK, Li, C, Feitosa, MF, Richard, MA, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, TM, Ding, J, Dorajoo, R, Manning, AK, Rankinen, T, Smith, AV, Tajuddin, SM, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, JF, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, SE, Hartwig, FP, He, M, Horimoto, ARVR, Hsu, F-C, Hung, Y-J & Murray, AD 2019, 'Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies novel loci associated with serum lipids' Nature Genetics, vol. 51, no. 4, pp. 636-648. https://doi.org/10.1038/s41588-019-0378-y
COGENT-Kidney Consortium ; Bentley, Amy R ; Sung, Yun J ; Brown, Michael R ; Winkler, Thomas W ; Kraja, Aldi T ; Ntalla, Ioanna ; Schwander, Karen ; Chasman, Daniel I ; Lim, Elise ; Deng, Xuan ; Guo, Xiuqing ; Liu, Jingmin ; Lu, Yingchang ; Cheng, Ching-Yu ; Sim, Xueling ; Vojinovic, Dina ; Huffman, Jennifer E ; Musani, Solomon K ; Li, Changwei ; Feitosa, Mary F ; Richard, Melissa A ; Noordam, Raymond ; Baker, Jenna ; Chen, Guanjie ; Aschard, Hugues ; Bartz, Traci M ; Ding, Jingzhong ; Dorajoo, Rajkumar ; Manning, Alisa K ; Rankinen, Tuomo ; Smith, Albert V ; Tajuddin, Salman M ; Zhao, Wei ; Graff, Mariaelisa ; Alver, Maris ; Boissel, Mathilde ; Chai, Jin Fang ; Chen, Xu ; Divers, Jasmin ; Evangelou, Evangelos ; Gao, Chuan ; Goel, Anuj ; Hagemeijer, Yanick ; Harris, Sarah E ; Hartwig, Fernando P ; He, Meian ; Horimoto, Andrea R V R ; Hsu, Fang-Chi ; Hung, Yi-Jen ; Murray, Alison D. / Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies novel loci associated with serum lipids. In: Nature Genetics. 2019 ; Vol. 51, No. 4. pp. 636-648.
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abstract = "The concentrations of high- and low-density lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 novel loci, some of which were detected only because the association differed by smoking status. Additionally, we demonstrated the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.",
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T1 - Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies novel loci associated with serum lipids

AU - COGENT-Kidney Consortium

AU - Bentley, Amy R

AU - Sung, Yun J

AU - Brown, Michael R

AU - Winkler, Thomas W

AU - Kraja, Aldi T

AU - Ntalla, Ioanna

AU - Schwander, Karen

AU - Chasman, Daniel I

AU - Lim, Elise

AU - Deng, Xuan

AU - Guo, Xiuqing

AU - Liu, Jingmin

AU - Lu, Yingchang

AU - Cheng, Ching-Yu

AU - Sim, Xueling

AU - Vojinovic, Dina

AU - Huffman, Jennifer E

AU - Musani, Solomon K

AU - Li, Changwei

AU - Feitosa, Mary F

AU - Richard, Melissa A

AU - Noordam, Raymond

AU - Baker, Jenna

AU - Chen, Guanjie

AU - Aschard, Hugues

AU - Bartz, Traci M

AU - Ding, Jingzhong

AU - Dorajoo, Rajkumar

AU - Manning, Alisa K

AU - Rankinen, Tuomo

AU - Smith, Albert V

AU - Tajuddin, Salman M

AU - Zhao, Wei

AU - Graff, Mariaelisa

AU - Alver, Maris

AU - Boissel, Mathilde

AU - Chai, Jin Fang

AU - Chen, Xu

AU - Divers, Jasmin

AU - Evangelou, Evangelos

AU - Gao, Chuan

AU - Goel, Anuj

AU - Hagemeijer, Yanick

AU - Harris, Sarah E

AU - Hartwig, Fernando P

AU - He, Meian

AU - Horimoto, Andrea R V R

AU - Hsu, Fang-Chi

AU - Hung, Yi-Jen

AU - Murray, Alison D

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PY - 2019/4

Y1 - 2019/4

N2 - The concentrations of high- and low-density lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 novel loci, some of which were detected only because the association differed by smoking status. Additionally, we demonstrated the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

AB - The concentrations of high- and low-density lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 novel loci, some of which were detected only because the association differed by smoking status. Additionally, we demonstrated the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

KW - cardiovascular diseases

KW - genome wide association studies

KW - genomics

KW - ENVIRONMENT INTERACTION

KW - METAANALYSIS

KW - CHOLESTEROL

KW - CIGARETTES

KW - VARIANTS

KW - SUSCEPTIBILITY

KW - NICOTINE METABOLISM

KW - RISK LOCI

KW - GENOTYPE IMPUTATION

KW - ARCHITECTURE

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UR - http://www.mendeley.com/research/multiancestry-genomewide-genesmoking-interaction-study-387272-individuals-identifies-new-loci-associ

U2 - 10.1038/s41588-019-0378-y

DO - 10.1038/s41588-019-0378-y

M3 - Article

VL - 51

SP - 636

EP - 648

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 4

ER -