Multi-mycotoxin exposure assessment in UK children using urinary biomarkers - a pilot survey

Silvia W Gratz, Valerie Currie, Gary Duncan, Diane Jackson

Research output: Contribution to journalArticle

Abstract

Cereal foods are commonly contaminated with multiple mycotoxins resulting in frequent human mycotoxin exposure. Children are at risk of high-level exposure due to their high cereal intake relative to body weight. Hence this study aims to assess multi-mycotoxin exposure in UK children using urinary biomarkers. Spot urines (n=21) were analysed for multi-mycotoxins (deoxynivalenol, DON; nivalenol, NIV; ochratoxin A, OTA; zearalenone, ZEN; α- zearalenol, α-ZEL; β-zearalenol, β-ZEL; T-2 toxin, T-2; HT-2 toxin, HT-2; aflatoxin B1 and M1, AFB1, AFM1) using liquid chromatography-coupled tandem mass spectrometry. Urine samples frequently contained DON (13.10±12.69 ng/mL), NIV (0.36±0.16 ng/mL), OTA (0.05±0.02 ng/mL) and ZEN (0.09±0.07 ng/mL). Some (1-3) samples contained T-2, HT-2, α-ZEL and β-ZEL, but not aflatoxins. Dietary mycotoxin estimation showed that children were frequently exposed to levels exceeding the tolerable daily intake (52% and 95% of cases for DON and OTA). This demonstrates that UK children are exposed to multiple mycotoxins through their habitual diet.

Original languageEnglish
Pages (from-to)351-357
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume68
Issue number1
Early online date12 Dec 2019
DOIs
Publication statusPublished - 2020

Fingerprint

exposure assessment
Mycotoxins
Biomarkers
mycotoxins
biomarkers
zearalenol
urine
Aflatoxin M1
Urine
T-2 Toxin
HT-2 toxin
Zearalenone
grain foods
No-Observed-Adverse-Effect Level
aflatoxin M1
nivalenol
T-2 toxin
acceptable daily intake
Aflatoxin B1
Aflatoxins

Keywords

  • trichothecenes
  • deoxynivalenol
  • ochratoxin
  • zearalenone
  • tolerable daily intake
  • co-exposure
  • diet

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Multi-mycotoxin exposure assessment in UK children using urinary biomarkers - a pilot survey. / Gratz, Silvia W; Currie, Valerie; Duncan, Gary; Jackson, Diane.

In: Journal of Agricultural and Food Chemistry, Vol. 68, No. 1, 2020, p. 351-357.

Research output: Contribution to journalArticle

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