Multi-target action of β-alanine protects cerebellar tissue from ischemic damage

Olga Kopach, Dmitri A Rusakov, Sergiy Sylantyev

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Brain ischemic stroke is among the leading causes of death and long-term disability. New treatments that alleviate brain cell damage until blood supply is restored are urgently required. The emerging focus of anti-stroke strategies has been on blood-brain-barrier permeable drugs that exhibit multiple sites of action. Here, we combine single-cell electrophysiology with live-cell imaging to find that β-Alanine (β-Ala) protects key physiological functions of brain cells that are exposed to acute stroke-mimicking conditions in ex vivo brain preparations. β-Ala exerts its neuroprotective action through several distinct pharmacological mechanisms, none of which alone could reproduce the neuroprotective effect. Since β-Ala crosses the blood-brain barrier and is part of a normal human diet, we suggest that it has a strong potential for acute stroke treatment and facilitation of recovery.

Original languageEnglish
Article number747
Number of pages11
JournalCell Death & Disease
Issue number8
Early online date29 Aug 2022
Publication statusPublished - 29 Aug 2022


  • Brain
  • Brain Injuries/drug therapy
  • Brain Ischemia/drug therapy
  • Humans
  • Neuroprotective Agents/pharmacology
  • Stroke/drug therapy
  • beta-Alanine/pharmacology


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