Multifunctional Deuterated and Tritiated “Click” Molecular Probes via Pd-mediated Reductive De-iodination of 5-Iodo-1,2,3-Triazoles

Andrea Testa, Monica Piras, Mike J Hickey, Ian N. Fleming, Nicholas Bushby, Eva Lenz, Charles S. Elmore, Matteo Zanda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Tritiated compounds are invaluable tools for in vitro and in vivo studies on bioactive molecules. Here we describe a ‘click-chemistry’-based strategy for deuteration and tritiation of multifunctional compounds and multimodal molecular imaging probes. The method relies on a palladium-mediated reductive deiodination of 5-iodo-1,2,3-triazoles in the presence of NaBD4, deuterium or tritium gas.
Original languageEnglish
Pages (from-to)1019-1025
Number of pages7
JournalSynlett
Volume25
Issue number07
DOIs
Publication statusPublished - Apr 2014

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Molecular imaging
Molecular Probes
Tritium
Deuterium
Palladium
Gases
Molecules
5-iodo-1,2,3-triazole

Keywords

  • tritium
  • ‘click’ chemistry
  • 1,2,3-triazole
  • deuterium
  • bioconjugation

Cite this

Multifunctional Deuterated and Tritiated “Click” Molecular Probes via Pd-mediated Reductive De-iodination of 5-Iodo-1,2,3-Triazoles. / Testa, Andrea; Piras, Monica; Hickey, Mike J ; Fleming, Ian N.; Bushby, Nicholas; Lenz, Eva; Elmore, Charles S.; Zanda, Matteo.

In: Synlett, Vol. 25, No. 07, 04.2014, p. 1019-1025.

Research output: Contribution to journalArticle

Testa, Andrea ; Piras, Monica ; Hickey, Mike J ; Fleming, Ian N. ; Bushby, Nicholas ; Lenz, Eva ; Elmore, Charles S. ; Zanda, Matteo. / Multifunctional Deuterated and Tritiated “Click” Molecular Probes via Pd-mediated Reductive De-iodination of 5-Iodo-1,2,3-Triazoles. In: Synlett. 2014 ; Vol. 25, No. 07. pp. 1019-1025.
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AU - Hickey, Mike J

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AU - Bushby, Nicholas

AU - Lenz, Eva

AU - Elmore, Charles S.

AU - Zanda, Matteo

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KW - bioconjugation

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