Multiple facets of macrophages in renal injury

D. C. Kluth, Lars Peter Erwig, Andrew Jackson Rees

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Macrophage infiltration is a common feature of renal disease and their presence has been synonymous with tissue damage and progressive renal failure. More recently work has focused on the heterogeneity of macrophage activation and in particular their ability to curtail inflammation and restore normal function. This has led to the view that it is macrophage function rather than their number that is important in determining the outcome of inflammatory disease. This review will focus on the pathways that regulate macrophage infiltration and activation and how these could be manipulated to control renal inflammatory disease. In particular, the ability of specific cell surface receptors and intracellular signaling pathways to control macrophage activation and how macrophages can be genetically manipulated to develop properties that favor resolution over ongoing injury.

Original languageEnglish
Pages (from-to)542-557
Number of pages16
JournalKidney International
Volume66
Issue number2
DOIs
Publication statusPublished - Aug 2004

Keywords

  • macrophages
  • inflammation
  • glomerulonephritis
  • cell therapy
  • monocyte chemoattractant protein-1
  • tumor-necrosis-factor
  • NF-kappa-B
  • experimental crescentic glomerulonephritis
  • migration inhibitory factor
  • interleukin-1 receptor antagonist
  • anti-gbm glomerulonephritis
  • collagen-induced arthritis
  • toll-like receptors
  • basement-membrane glomerulonephritis

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