Multiple genetic loci modify risk for retinoblastoma in transgenic mice

A E Griep, J Krawcek, D Lee, A Liem, D M Albert, R Carabeo, N Drinkwater, M McCall, C Sattler, J G Lasudry, P F Lambert

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29 Citations (Scopus)

Abstract

Forty percent of cases of retinoblastoma, a childhood malignancy of the retina, are linked to the inheritance of a mutant allele of the retinoblastoma susceptibility gene Rb1. Tumor penetrance varies among carriers in different family pedigrees, indicating that other genetic factors may modify risk for occurrence of retinoblastoma. This study was undertaken to determine whether multiple genetic loci modify the risk for retinoblastoma in mice.
Original languageEnglish
Pages (from-to)2723-32
Number of pages10
JournalInvestigative Ophthalmology & Visual Science
Volume39
Issue number13
Publication statusPublished - Dec 1998

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Keywords

  • Retinal Neoplasms
  • Animals
  • Tumor Suppressor Protein p53
  • Retinoblastoma Protein
  • Retina
  • DNA-Binding Proteins
  • Papillomavirus E7 Proteins
  • Papillomaviridae
  • Mice
  • Retinoblastoma
  • Mice, Transgenic
  • Genotype
  • In Situ Hybridization
  • Oncogene Proteins, Viral
  • Risk Factors
  • DNA Primers
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Antigens, Polyomavirus Transforming
  • Female
  • Male

Cite this

Griep, A. E., Krawcek, J., Lee, D., Liem, A., Albert, D. M., Carabeo, R., ... Lambert, P. F. (1998). Multiple genetic loci modify risk for retinoblastoma in transgenic mice. Investigative Ophthalmology & Visual Science, 39(13), 2723-32.