Multistability of synthetic genetic networks with repressive cell-to-cell communication

Ekkehard Ullner, Aneta Koseska, Jurgen Kurths, Evgenii Volkov, Holger Kantz, Jordi García-Ojalvo

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

We investigate an experimentally feasible synthetic genetic network consisting of two phase repulsively
coupled repressilators, which evokes multiple coexisting stable attractors with different features. We perform a
bifurcation analysis to determine and classify the dynamical structure of the system. Moreover, some of the
dynamical regimes found, such as inhomogeneous steady states and inhomogeneous limit cycles can further be
associated with artificial cell differentiation. We also report and characterize the emergence of chaotic dynamics
resulting from the intercell coupling.
Original languageEnglish
Article number031904
Number of pages8
JournalPhysical Review. E, Statistical, Nonlinear and Soft Matter Physics
Volume78
Issue number3
DOIs
Publication statusPublished - 5 Sep 2008

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Cell Communication
Multistability
Genetic Network
communication
Cell Differentiation
cycles
Cell
cells
Limit Cycle
Attractor
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Multistability of synthetic genetic networks with repressive cell-to-cell communication. / Ullner, Ekkehard; Koseska, Aneta; Kurths, Jurgen; Volkov, Evgenii; Kantz, Holger; García-Ojalvo, Jordi.

In: Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, Vol. 78, No. 3, 031904, 05.09.2008.

Research output: Contribution to journalArticle

Ullner, Ekkehard ; Koseska, Aneta ; Kurths, Jurgen ; Volkov, Evgenii ; Kantz, Holger ; García-Ojalvo, Jordi. / Multistability of synthetic genetic networks with repressive cell-to-cell communication. In: Physical Review. E, Statistical, Nonlinear and Soft Matter Physics. 2008 ; Vol. 78, No. 3.
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