Muscle and whole body metabolism after norepinephrine

A V Kurpad, K Khan, Alexander Graham Calder, M Elia

    Research output: Contribution to journalArticle

    45 Citations (Scopus)

    Abstract

    The effect of an infusion of norepinephrine (0.42 nmol.kg-1.min-1) on energy metabolism in the whole body (using indirect calorimetry and the arteriovenous forearm catheterization techniques in eight healthy young male adults. The activity of the triglyceride-fatty acid cycle, which mainly operates in nonmuscular tissues, was also assessed by measuring glycerol turnover using [2H5]glycerol (to indicate lipolysis) and indirect calorimetry (to indicate net fat oxidation). Norepinephrine increased whole body oxygen consumption by almost 10% (P <0.01), but the estimated oxygen consumption of muscles tended to decrease. Muscle blood flow (measured by 133Xe) and forearm blood flow (measured by strain-gauge plethysmography) were not significantly affected by norepinephrine, but the rate of uptake of nonesterified fatty acids and beta-hydroxybutyrate increased severalfold (P <0.05), whereas that of glucose did not. The activity of the triglyceride-fatty acid cycle increased fourfold after norepinephrine administration, having a marginal effect on resting energy expenditure (approximately 1.5%) but accounting for approximately 15% of the increase in whole body energy expenditure. This study provides no evidence that skeletal muscle is an important site for norepinephrine-induced thermogenesis and suggests that an increase in the activity of the triglyceride-fatty acid cycle contributes to the norepinephrine-induced increase in energy expenditure of nonmuscular tissues.
    Original languageEnglish
    Pages (from-to)E877-84
    Number of pages8
    JournalAmerican Journal of Physiology: Endocrinology and Metabolism
    Volume266
    Issue number6
    Publication statusPublished - 1 Jun 1994

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    Norepinephrine
    Muscles
    Energy Metabolism
    Indirect Calorimetry
    Triglycerides
    Fatty Acids
    Forearm
    Oxygen Consumption
    Glycerol
    Plethysmography
    3-Hydroxybutyric Acid
    Thermogenesis
    Lipolysis
    Nonesterified Fatty Acids
    Catheterization
    Young Adult
    Skeletal Muscle
    Fats
    Glucose

    Keywords

    • Adult
    • Body Temperature
    • Body Temperature Regulation
    • Energy Metabolism
    • Fatty Acids
    • Fatty Acids, Nonesterified
    • Forearm
    • Glycerol
    • Humans
    • Male
    • Muscles
    • Norepinephrine
    • Regional Blood Flow
    • Skin Temperature

    Cite this

    Kurpad, A. V., Khan, K., Calder, A. G., & Elia, M. (1994). Muscle and whole body metabolism after norepinephrine. American Journal of Physiology: Endocrinology and Metabolism, 266(6), E877-84.

    Muscle and whole body metabolism after norepinephrine. / Kurpad, A V; Khan, K; Calder, Alexander Graham; Elia, M.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 266, No. 6, 01.06.1994, p. E877-84.

    Research output: Contribution to journalArticle

    Kurpad, AV, Khan, K, Calder, AG & Elia, M 1994, 'Muscle and whole body metabolism after norepinephrine', American Journal of Physiology: Endocrinology and Metabolism, vol. 266, no. 6, pp. E877-84.
    Kurpad, A V ; Khan, K ; Calder, Alexander Graham ; Elia, M. / Muscle and whole body metabolism after norepinephrine. In: American Journal of Physiology: Endocrinology and Metabolism. 1994 ; Vol. 266, No. 6. pp. E877-84.
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    AB - The effect of an infusion of norepinephrine (0.42 nmol.kg-1.min-1) on energy metabolism in the whole body (using indirect calorimetry and the arteriovenous forearm catheterization techniques in eight healthy young male adults. The activity of the triglyceride-fatty acid cycle, which mainly operates in nonmuscular tissues, was also assessed by measuring glycerol turnover using [2H5]glycerol (to indicate lipolysis) and indirect calorimetry (to indicate net fat oxidation). Norepinephrine increased whole body oxygen consumption by almost 10% (P <0.01), but the estimated oxygen consumption of muscles tended to decrease. Muscle blood flow (measured by 133Xe) and forearm blood flow (measured by strain-gauge plethysmography) were not significantly affected by norepinephrine, but the rate of uptake of nonesterified fatty acids and beta-hydroxybutyrate increased severalfold (P <0.05), whereas that of glucose did not. The activity of the triglyceride-fatty acid cycle increased fourfold after norepinephrine administration, having a marginal effect on resting energy expenditure (approximately 1.5%) but accounting for approximately 15% of the increase in whole body energy expenditure. This study provides no evidence that skeletal muscle is an important site for norepinephrine-induced thermogenesis and suggests that an increase in the activity of the triglyceride-fatty acid cycle contributes to the norepinephrine-induced increase in energy expenditure of nonmuscular tissues.

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