Mycobiota dysbiosis: a new nexus in intestinal tumorigenesis

Nicolas Papon*, Gordon D. Brown, Neil A.R. Gow

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

Abstract

While there is growing evidence that perturbation of the gut microbiota can result in a variety of pathologies including gut tumorigenesis, the influence of commensal fungi remains less clear. In this issue, Zhu et al (2021) show that mycobiota dysbiosis stimulates energy metabolism changes in subepithelial macrophages promoting colon cancer via enhancing innate lymphoid cell activity. These findings provide insights into a role of the gut flora in intestinal carcinogenesis and suggest opportunities for adjunctive antifungal or immunotherapeutic strategies to prevent colorectal cancer.

Original languageEnglish
Article number e108175
Number of pages3
JournalEMBO Journal
Volume2021
DOIs
Publication statusPublished - 6 Apr 2021

Fingerprint Dive into the research topics of 'Mycobiota dysbiosis: a new nexus in intestinal tumorigenesis'. Together they form a unique fingerprint.

Cite this