Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice

Andrej Fokin, Petras Minderis, Tomas Venckunas, Arimantas Lionikas, Mindaugas Kvedaras, Aivaras Ratkevicius

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting.

METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied.

RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline.

CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting.

Original languageEnglish
Pages (from-to)342-353
Number of pages12
JournalJournal of musculoskeletal & neuronal interactions
Volume19
Issue number3
Publication statusPublished - 1 Sep 2019

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Myostatin
Berlin
Fasting
Muscles
Food Deprivation
Skeletal Muscle
Body Composition

Keywords

  • myostatin
  • caloric restriction
  • fasting
  • muscle atrophy
  • muscle specific force

Cite this

Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice. / Fokin, Andrej; Minderis, Petras; Venckunas, Tomas; Lionikas, Arimantas; Kvedaras, Mindaugas; Ratkevicius, Aivaras.

In: Journal of musculoskeletal & neuronal interactions, Vol. 19, No. 3, 01.09.2019, p. 342-353.

Research output: Contribution to journalArticle

Fokin, A, Minderis, P, Venckunas, T, Lionikas, A, Kvedaras, M & Ratkevicius, A 2019, 'Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice', Journal of musculoskeletal & neuronal interactions, vol. 19, no. 3, pp. 342-353.
Fokin, Andrej ; Minderis, Petras ; Venckunas, Tomas ; Lionikas, Arimantas ; Kvedaras, Mindaugas ; Ratkevicius, Aivaras. / Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice. In: Journal of musculoskeletal & neuronal interactions. 2019 ; Vol. 19, No. 3. pp. 342-353.
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AU - Fokin, Andrej

AU - Minderis, Petras

AU - Venckunas, Tomas

AU - Lionikas, Arimantas

AU - Kvedaras, Mindaugas

AU - Ratkevicius, Aivaras

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N2 - OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting.METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied.RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline.CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting.

AB - OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting.METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied.RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline.CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting.

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