Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice

Andrej Fokin, Petras Minderis, Tomas Venckunas, Arimantas Lionikas, Mindaugas Kvedaras, Aivaras Ratkevicius

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Abstract

OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting.

METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied.

RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline.

CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting.

Original languageEnglish
Pages (from-to)342-353
Number of pages12
JournalJournal of musculoskeletal & neuronal interactions
Volume19
Issue number3
Publication statusPublished - 1 Sep 2019

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Keywords

  • myostatin
  • caloric restriction
  • fasting
  • muscle atrophy
  • muscle specific force

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