Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice

Andrej Fokin; Petras Minderis; Tomas Venckunas; Arimantas Lionikas; Mindaugas Kvedaras; Aivaras Ratkevicius

Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice

Andrej Fokin, Petras Minderis, Tomas Venckunas, Arimantas Lionikas, Mindaugas Kvedaras, Aivaras Ratkevicius

Lithuanian Sports University

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

6 Downloads (Pure)

Abstract

OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting.

METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied.

RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline.

CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting.

Original language	English
Pages (from-to)	342-353
Number of pages	12
Journal	Journal of musculoskeletal & neuronal interactions
Volume	19
Issue number	3
Publication status	Published - 1 Sept 2019

Keywords

myostatin
caloric restriction
fasting
muscle atrophy
muscle specific force

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Cite this

@article{95bd22a9d3f24e2ab668bf5cfacbc8ca,

title = "Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice",

abstract = "OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting.METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied.RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline.CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting.",

keywords = "myostatin, caloric restriction, fasting, muscle atrophy, muscle specific force",

author = "Andrej Fokin and Petras Minderis and Tomas Venckunas and Arimantas Lionikas and Mindaugas Kvedaras and Aivaras Ratkevicius",

year = "2019",

month = sep,

day = "1",

language = "English",

volume = "19",

pages = "342--353",

journal = "Journal of musculoskeletal & neuronal interactions",

issn = "1108-7161",

publisher = "International Society of Musculoskeletal and Neuronal Interactions",

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TY - JOUR

T1 - Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice

AU - Fokin, Andrej

AU - Minderis, Petras

AU - Venckunas, Tomas

AU - Lionikas, Arimantas

AU - Kvedaras, Mindaugas

AU - Ratkevicius, Aivaras

PY - 2019/9/1

Y1 - 2019/9/1

N2 - OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting.METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied.RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline.CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting.

AB - OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting.METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied.RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline.CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting.

KW - myostatin

KW - caloric restriction

KW - fasting

KW - muscle atrophy

KW - muscle specific force

M3 - Article

C2 - 31475942

SN - 1108-7161

VL - 19

SP - 342

EP - 353

JO - Journal of musculoskeletal & neuronal interactions

JF - Journal of musculoskeletal & neuronal interactions

IS - 3

ER -

Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice

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Keywords

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