Nasal immunity is an ancient arm of the mucosal immune system of vertebrates

Luca Tacchi; Rami Musharrafieh; Erin T Larragoite; Kyle Crossey; Erik B Erhardt; Samuel A M Martin; Scott E LaPatra; Irene Salinas

doi:10.1038/ncomms6205

Nasal immunity is an ancient arm of the mucosal immune system of vertebrates

Luca Tacchi, Rami Musharrafieh, Erin T Larragoite, Kyle Crossey, Erik B Erhardt, Samuel A M Martin, Scott E LaPatra, Irene Salinas^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

161 Citations (Scopus)

Abstract

The mucosal surfaces of all vertebrates have been exposed to similar evolutionary pressures for millions of years. In terrestrial vertebrates such as birds and mammals, the nasopharynx-associated lymphoid tissue (NALT) represents a first line of immune defence. Here we propose that NALT is an ancient arm of the mucosal immune system not restricted to terrestrial vertebrates. We find that NALT is present in rainbow trout and that it resembles other teleost mucosa-associated lymphoid tissues. Trout NALT consists of diffuse lymphoid cells and lacks tonsils and adenoids. The predominant B-cell subset found in trout NALT are IgT(+) B cells, similar to skin and gut. The trout olfactory organ is colonized by abundant symbiotic bacteria, which are coated by trout secretory immunoglobulin. Trout NALT is capable of mounting strong anti-viral immune responses following nasal delivery of a live attenuated viral vaccine. Our results open up a new tool for the control of aquatic infectious diseases via nasal vaccination.

Original language	English
Article number	5205
Number of pages	11
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms6205
Publication status	Published - 22 Oct 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ncomms6205Licence: Unspecified

https://static-content.springer.com/esm/art%3A10.1038%2Fncomms6205/MediaObjects/41467_2014_BFncomms6205_MOESM344_ESM.pdfLicence: Unspecified

Samuel Martin
Person: Academic

Cite this

@article{1f3b6547654c4165b0cfee715f77b38a,

title = "Nasal immunity is an ancient arm of the mucosal immune system of vertebrates",

abstract = "The mucosal surfaces of all vertebrates have been exposed to similar evolutionary pressures for millions of years. In terrestrial vertebrates such as birds and mammals, the nasopharynx-associated lymphoid tissue (NALT) represents a first line of immune defence. Here we propose that NALT is an ancient arm of the mucosal immune system not restricted to terrestrial vertebrates. We find that NALT is present in rainbow trout and that it resembles other teleost mucosa-associated lymphoid tissues. Trout NALT consists of diffuse lymphoid cells and lacks tonsils and adenoids. The predominant B-cell subset found in trout NALT are IgT(+) B cells, similar to skin and gut. The trout olfactory organ is colonized by abundant symbiotic bacteria, which are coated by trout secretory immunoglobulin. Trout NALT is capable of mounting strong anti-viral immune responses following nasal delivery of a live attenuated viral vaccine. Our results open up a new tool for the control of aquatic infectious diseases via nasal vaccination.",

author = "Luca Tacchi and Rami Musharrafieh and Larragoite, {Erin T} and Kyle Crossey and Erhardt, {Erik B} and Martin, {Samuel A M} and LaPatra, {Scott E} and Irene Salinas",

year = "2014",

month = oct,

day = "22",

doi = "10.1038/ncomms6205",

language = "English",

volume = "5",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Nasal immunity is an ancient arm of the mucosal immune system of vertebrates

AU - Tacchi, Luca

AU - Musharrafieh, Rami

AU - Larragoite, Erin T

AU - Crossey, Kyle

AU - Erhardt, Erik B

AU - Martin, Samuel A M

AU - LaPatra, Scott E

AU - Salinas, Irene

PY - 2014/10/22

Y1 - 2014/10/22

N2 - The mucosal surfaces of all vertebrates have been exposed to similar evolutionary pressures for millions of years. In terrestrial vertebrates such as birds and mammals, the nasopharynx-associated lymphoid tissue (NALT) represents a first line of immune defence. Here we propose that NALT is an ancient arm of the mucosal immune system not restricted to terrestrial vertebrates. We find that NALT is present in rainbow trout and that it resembles other teleost mucosa-associated lymphoid tissues. Trout NALT consists of diffuse lymphoid cells and lacks tonsils and adenoids. The predominant B-cell subset found in trout NALT are IgT(+) B cells, similar to skin and gut. The trout olfactory organ is colonized by abundant symbiotic bacteria, which are coated by trout secretory immunoglobulin. Trout NALT is capable of mounting strong anti-viral immune responses following nasal delivery of a live attenuated viral vaccine. Our results open up a new tool for the control of aquatic infectious diseases via nasal vaccination.

AB - The mucosal surfaces of all vertebrates have been exposed to similar evolutionary pressures for millions of years. In terrestrial vertebrates such as birds and mammals, the nasopharynx-associated lymphoid tissue (NALT) represents a first line of immune defence. Here we propose that NALT is an ancient arm of the mucosal immune system not restricted to terrestrial vertebrates. We find that NALT is present in rainbow trout and that it resembles other teleost mucosa-associated lymphoid tissues. Trout NALT consists of diffuse lymphoid cells and lacks tonsils and adenoids. The predominant B-cell subset found in trout NALT are IgT(+) B cells, similar to skin and gut. The trout olfactory organ is colonized by abundant symbiotic bacteria, which are coated by trout secretory immunoglobulin. Trout NALT is capable of mounting strong anti-viral immune responses following nasal delivery of a live attenuated viral vaccine. Our results open up a new tool for the control of aquatic infectious diseases via nasal vaccination.

U2 - 10.1038/ncomms6205

DO - 10.1038/ncomms6205

M3 - Article

C2 - 25335508

SN - 2041-1723

VL - 5

JO - Nature Communications

JF - Nature Communications

M1 - 5205

ER -

Nasal immunity is an ancient arm of the mucosal immune system of vertebrates

Abstract

UN SDGs

Access to Document

Fingerprint

Profiles

Samuel Martin

Cite this