Nasal immunity is an ancient arm of the mucosal immune system of vertebrates

Luca Tacchi, Rami Musharrafieh, Erin T Larragoite, Kyle Crossey, Erik B Erhardt, Samuel A M Martin, Scott E LaPatra, Irene Salinas

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The mucosal surfaces of all vertebrates have been exposed to similar evolutionary pressures for millions of years. In terrestrial vertebrates such as birds and mammals, the nasopharynx-associated lymphoid tissue (NALT) represents a first line of immune defence. Here we propose that NALT is an ancient arm of the mucosal immune system not restricted to terrestrial vertebrates. We find that NALT is present in rainbow trout and that it resembles other teleost mucosa-associated lymphoid tissues. Trout NALT consists of diffuse lymphoid cells and lacks tonsils and adenoids. The predominant B-cell subset found in trout NALT are IgT(+) B cells, similar to skin and gut. The trout olfactory organ is colonized by abundant symbiotic bacteria, which are coated by trout secretory immunoglobulin. Trout NALT is capable of mounting strong anti-viral immune responses following nasal delivery of a live attenuated viral vaccine. Our results open up a new tool for the control of aquatic infectious diseases via nasal vaccination.

Original languageEnglish
Article number5205
JournalNature Communications
Volume5
DOIs
Publication statusPublished - 22 Oct 2014

Fingerprint

immune systems
vertebrates
Immune system
immunity
Lymphoid Tissue
Nasopharynx
Nose
Vertebrates
Immune System
Immunity
Trout
Tissue
Cells
Viral Vaccines
vaccines
B-Lymphocyte Subsets
Adenoids
Attenuated Vaccines
mammals
Mammals

Cite this

Tacchi, L., Musharrafieh, R., Larragoite, E. T., Crossey, K., Erhardt, E. B., Martin, S. A. M., ... Salinas, I. (2014). Nasal immunity is an ancient arm of the mucosal immune system of vertebrates. Nature Communications, 5, [5205]. https://doi.org/10.1038/ncomms6205

Nasal immunity is an ancient arm of the mucosal immune system of vertebrates. / Tacchi, Luca; Musharrafieh, Rami; Larragoite, Erin T; Crossey, Kyle; Erhardt, Erik B; Martin, Samuel A M; LaPatra, Scott E; Salinas, Irene.

In: Nature Communications, Vol. 5, 5205, 22.10.2014.

Research output: Contribution to journalArticle

Tacchi, L, Musharrafieh, R, Larragoite, ET, Crossey, K, Erhardt, EB, Martin, SAM, LaPatra, SE & Salinas, I 2014, 'Nasal immunity is an ancient arm of the mucosal immune system of vertebrates', Nature Communications, vol. 5, 5205. https://doi.org/10.1038/ncomms6205
Tacchi, Luca ; Musharrafieh, Rami ; Larragoite, Erin T ; Crossey, Kyle ; Erhardt, Erik B ; Martin, Samuel A M ; LaPatra, Scott E ; Salinas, Irene. / Nasal immunity is an ancient arm of the mucosal immune system of vertebrates. In: Nature Communications. 2014 ; Vol. 5.
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