Natural killer receptor repertoires in transplantation

D C Jones, Neil Thomas Young

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Natural killer (NK) lymphocytes are potent effector cells that are controlled by the expression of a variety of cell surface receptors with either inhibitory or activating functions. The genetic and functional diversity of this receptor repertoire and the role of HLA class I molecules as a major group of NK receptor ligands create an innate alloreactive capacity in this cell type. Both animal models and in vitro studies have implicated NK cells as contributors to the pathology of clinical transplantation. However, recent clinical studies have indicated the potential benefit of exploiting NK cell alloreactivity in mismatched haematopoietic stem cell transplantation. Further investigations of NK cell alloreactivity will undoubtedly reveal additional applications of this fundamental cell type in clinical transplantation.
Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalEuropean Journal of Immunogenetics
Volume30
Issue number3
DOIs
Publication statusPublished - 1 Jun 2003

Keywords

  • Animals
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Killer Cells, Natural
  • Organ Transplantation
  • Receptors, Immunologic
  • T-Lymphocytes
  • Transplantation Immunology
  • Virus Diseases

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