Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene

Thomas M Lancaster, Alison Baird, Claudia Wolf, Margaret C Jackson, Stephen J Johnston, Rossen Donev, Johannes Thome, David E J Linden

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Abstract

Recent GWAS identified a risk variant for Alzheimer's disease (AD) at a locus (rs11136000) of the clusterin gene (CLU). Here we use functional magnetic resonance imaging (fMRI) during working memory to probe the effect of the risk variant on brain activation in healthy individuals. Participants with the CLU risk genotype had higher activity than participants with the protective allele in frontal and posterior cingulate cortex and the hippocampus, particularly during high memory demand. These results inform pathophysiological models of the preclinical progression of AD.
Original languageEnglish
Pages (from-to)880-884
Number of pages5
JournalEuropean Neuropsychopharmacology
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 2011

Keywords

  • dementia
  • genetic imaging
  • working memory
  • clusterin
  • hippocampus
  • prefrontal cortex

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