Neurodegenerativer Prozess bei Morbus Parkinson: Rolle der Myeloperoxidase

Peter Teismann

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Myeloperoxidase (MPO) is a hemoprotein which is involved in the unspecific immune response. In this process hypochloric acid is released. Hypochloric acid can react with lipids and proteins and thus lead to cell damage. We were able to show that MPO, as well as a biomarker for MPO – 3-Chlorotyrosine – are upregulated in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-model of Parkinson’s disease as well as in the disease itself. Ablation of MPO resulted in a neuroprotective effect in the MPTP-model. Herein we describe the different function of MPO, and how these can lead to the cellular demise as seen in Parkinson’s disease.
Original languageGerman
Pages (from-to)99-102
Number of pages4
JournalDeutsche medizinische Wochenschrift
Volume139
Issue number3
DOIs
Publication statusPublished - Jan 2014

Keywords

  • myeloperoxidase
  • Parkinson’s disease
  • MPTP
  • neutrophils
  • Aastrocytes
  • gliosis
  • neurodegeneration

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