Neuronal excitability level transition induced by electrical stimulation

G Florence; J Kurths; B S Machado; E T Fonoff; H A  Cerdeira; M J  Teixeira; K  Sameshima

doi:10.1140/epjst/e2014-02304-x

Neuronal excitability level transition induced by electrical stimulation

G Florence, J Kurths, B S Machado, E T Fonoff, H A Cerdeira, M J Teixeira, K Sameshima

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In experimental studies, electrical stimulation (ES) has been applied to induce neuronal activity or to disrupt pathological patterns. Nevertheless, the underlying mechanisms of these activity pattern transitions are not clear. To study these phenomena, we simulated a model of the hippocampal region CA1. The computational simulations using different amplitude levels and duration of ES revealed three states of neuronal excitability: burst-firing mode, depolarization block and spreading depression wave. We used the bifurcation theory to analyse the interference of ES in the cellular excitability and the neuronal dynamics. Understanding this process would help to improve the ES techniques to control some neurological disorders.

Original language	English
Pages (from-to)	2913-2922
Number of pages	10
Journal	The European Physical Journal. Special Topics
Volume	223
Issue number	13
Early online date	10 Dec 2014
DOIs	https://doi.org/10.1140/epjst/e2014-02304-x
Publication status	Published - Dec 2014

Bibliographical note

The authors thank FAPESP Grant 2011/21138-5 (G.F.), UNIEMP (B.S.M.) and CNPq
Grant 309381/2012-6 (K.S.) for supporting this research.

Access to Document

10.1140/epjst/e2014-02304-x

Cite this

@article{ab97c4f7efff4db88bd5da38c061aac3,

title = "Neuronal excitability level transition induced by electrical stimulation",

abstract = "In experimental studies, electrical stimulation (ES) has been applied to induce neuronal activity or to disrupt pathological patterns. Nevertheless, the underlying mechanisms of these activity pattern transitions are not clear. To study these phenomena, we simulated a model of the hippocampal region CA1. The computational simulations using different amplitude levels and duration of ES revealed three states of neuronal excitability: burst-firing mode, depolarization block and spreading depression wave. We used the bifurcation theory to analyse the interference of ES in the cellular excitability and the neuronal dynamics. Understanding this process would help to improve the ES techniques to control some neurological disorders.",

author = "G Florence and J Kurths and Machado, {B S} and Fonoff, {E T} and Cerdeira, {H A} and Teixeira, {M J} and K Sameshima",

note = "The authors thank FAPESP Grant 2011/21138-5 (G.F.), UNIEMP (B.S.M.) and CNPq Grant 309381/2012-6 (K.S.) for supporting this research.",

year = "2014",

month = dec,

doi = "10.1140/epjst/e2014-02304-x",

language = "English",

volume = "223",

pages = "2913--2922",

journal = "The European Physical Journal. Special Topics",

issn = "1951-6355",

publisher = "SPRINGER HEIDELBERG",

number = "13",

}

TY - JOUR

T1 - Neuronal excitability level transition induced by electrical stimulation

AU - Florence, G

AU - Kurths, J

AU - Machado, B S

AU - Fonoff, E T

AU - Cerdeira, H A

AU - Teixeira, M J

AU - Sameshima, K

N1 - The authors thank FAPESP Grant 2011/21138-5 (G.F.), UNIEMP (B.S.M.) and CNPq Grant 309381/2012-6 (K.S.) for supporting this research.

PY - 2014/12

Y1 - 2014/12

N2 - In experimental studies, electrical stimulation (ES) has been applied to induce neuronal activity or to disrupt pathological patterns. Nevertheless, the underlying mechanisms of these activity pattern transitions are not clear. To study these phenomena, we simulated a model of the hippocampal region CA1. The computational simulations using different amplitude levels and duration of ES revealed three states of neuronal excitability: burst-firing mode, depolarization block and spreading depression wave. We used the bifurcation theory to analyse the interference of ES in the cellular excitability and the neuronal dynamics. Understanding this process would help to improve the ES techniques to control some neurological disorders.

AB - In experimental studies, electrical stimulation (ES) has been applied to induce neuronal activity or to disrupt pathological patterns. Nevertheless, the underlying mechanisms of these activity pattern transitions are not clear. To study these phenomena, we simulated a model of the hippocampal region CA1. The computational simulations using different amplitude levels and duration of ES revealed three states of neuronal excitability: burst-firing mode, depolarization block and spreading depression wave. We used the bifurcation theory to analyse the interference of ES in the cellular excitability and the neuronal dynamics. Understanding this process would help to improve the ES techniques to control some neurological disorders.

U2 - 10.1140/epjst/e2014-02304-x

DO - 10.1140/epjst/e2014-02304-x

M3 - Article

SN - 1951-6355

VL - 223

SP - 2913

EP - 2922

JO - The European Physical Journal. Special Topics

JF - The European Physical Journal. Special Topics

IS - 13

ER -

Neuronal excitability level transition induced by electrical stimulation

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this