Neuronal excitability level transition induced by electrical stimulation

G Florence, J Kurths, B S Machado, E T Fonoff, H A Cerdeira, M J Teixeira, K Sameshima

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In experimental studies, electrical stimulation (ES) has been applied to induce neuronal activity or to disrupt pathological patterns. Nevertheless, the underlying mechanisms of these activity pattern transitions are not clear. To study these phenomena, we simulated a model of the hippocampal region CA1. The computational simulations using different amplitude levels and duration of ES revealed three states of neuronal excitability: burst-firing mode, depolarization block and spreading depression wave. We used the bifurcation theory to analyse the interference of ES in the cellular excitability and the neuronal dynamics. Understanding this process would help to improve the ES techniques to control some neurological disorders.
Original languageEnglish
Pages (from-to)2913-2922
Number of pages10
JournalThe European Physical Journal. Special Topics
Volume223
Issue number13
Early online date10 Dec 2014
DOIs
Publication statusPublished - Dec 2014

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Depolarization
stimulation
depolarization
bursts
disorders
interference
simulation

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Florence, G., Kurths, J., Machado, B. S., Fonoff, E. T., Cerdeira, H. A., Teixeira, M. J., & Sameshima, K. (2014). Neuronal excitability level transition induced by electrical stimulation. The European Physical Journal. Special Topics, 223(13), 2913-2922. https://doi.org/10.1140/epjst/e2014-02304-x

Neuronal excitability level transition induced by electrical stimulation. / Florence, G; Kurths, J; Machado, B S; Fonoff, E T; Cerdeira, H A ; Teixeira, M J ; Sameshima, K .

In: The European Physical Journal. Special Topics, Vol. 223, No. 13, 12.2014, p. 2913-2922.

Research output: Contribution to journalArticle

Florence, G, Kurths, J, Machado, BS, Fonoff, ET, Cerdeira, HA, Teixeira, MJ & Sameshima, K 2014, 'Neuronal excitability level transition induced by electrical stimulation', The European Physical Journal. Special Topics, vol. 223, no. 13, pp. 2913-2922. https://doi.org/10.1140/epjst/e2014-02304-x
Florence G, Kurths J, Machado BS, Fonoff ET, Cerdeira HA, Teixeira MJ et al. Neuronal excitability level transition induced by electrical stimulation. The European Physical Journal. Special Topics. 2014 Dec;223(13):2913-2922. https://doi.org/10.1140/epjst/e2014-02304-x
Florence, G ; Kurths, J ; Machado, B S ; Fonoff, E T ; Cerdeira, H A ; Teixeira, M J ; Sameshima, K . / Neuronal excitability level transition induced by electrical stimulation. In: The European Physical Journal. Special Topics. 2014 ; Vol. 223, No. 13. pp. 2913-2922.
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AU - Sameshima, K

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