Neuronal excitability level transition induced by electrical stimulation

G Florence, J Kurths, B S Machado, E T Fonoff, H A Cerdeira, M J Teixeira, K Sameshima

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


In experimental studies, electrical stimulation (ES) has been applied to induce neuronal activity or to disrupt pathological patterns. Nevertheless, the underlying mechanisms of these activity pattern transitions are not clear. To study these phenomena, we simulated a model of the hippocampal region CA1. The computational simulations using different amplitude levels and duration of ES revealed three states of neuronal excitability: burst-firing mode, depolarization block and spreading depression wave. We used the bifurcation theory to analyse the interference of ES in the cellular excitability and the neuronal dynamics. Understanding this process would help to improve the ES techniques to control some neurological disorders.
Original languageEnglish
Pages (from-to)2913-2922
Number of pages10
JournalThe European Physical Journal. Special Topics
Issue number13
Early online date10 Dec 2014
Publication statusPublished - Dec 2014


Dive into the research topics of 'Neuronal excitability level transition induced by electrical stimulation'. Together they form a unique fingerprint.

Cite this