Neuropathological findings in the very old - Results from the first 101 brains of a population-based longitudinal study of dementing disorders

J H Xuereb, C Brayne, C Dufouil, H Gertz, C Wischik, C Harrington, E Mukaetova-Ladinska, M A McGee, A O'Sullivan, D O'Connor, E S Paykel, F A Huppert

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Abstract

We report a unique Longitudinal epidemiological study of cognitive decline in the elderly population of the city of Cambridge, UK, A population sample of people aged 75 and over was surveyed between 1984-1996 (n = 2,616) and followed 2.4, 6, and 9 years later. CAMDEX diagnostic criteria were used for clinical assessment, and the neuropathological protocol (in 101 cases) was based on the CERAD method, with additional features to allow Braak staging of neurofibrillary pathology. The main findings are of the heterogeneity of lesions to be found in very old populations, and the existence of considerable overlap in the pathologies found in the demented and nondemented. It seems that white matter (ischemic) pallor an amyloid angiopathy, as well as neuritic plaques, neurofibrillary tangles and Lewy body formation are all lesions that increase the likelihood of dementia.

Original languageEnglish
Pages (from-to)490-496
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume903
Publication statusPublished - 2000

Keywords

  • ALZHEIMERS-DISEASE
  • PLAQUES
  • CERAD

Cite this

Neuropathological findings in the very old - Results from the first 101 brains of a population-based longitudinal study of dementing disorders. / Xuereb, J H ; Brayne, C ; Dufouil, C ; Gertz, H ; Wischik, C ; Harrington, C ; Mukaetova-Ladinska, E ; McGee, M A ; O'Sullivan, A ; O'Connor, D ; Paykel, E S ; Huppert, F A .

In: Annals of the New York Academy of Sciences, Vol. 903, 2000, p. 490-496.

Research output: Contribution to journalArticle

Xuereb, JH, Brayne, C, Dufouil, C, Gertz, H, Wischik, C, Harrington, C, Mukaetova-Ladinska, E, McGee, MA, O'Sullivan, A, O'Connor, D, Paykel, ES & Huppert, FA 2000, 'Neuropathological findings in the very old - Results from the first 101 brains of a population-based longitudinal study of dementing disorders', Annals of the New York Academy of Sciences, vol. 903, pp. 490-496.
Xuereb, J H ; Brayne, C ; Dufouil, C ; Gertz, H ; Wischik, C ; Harrington, C ; Mukaetova-Ladinska, E ; McGee, M A ; O'Sullivan, A ; O'Connor, D ; Paykel, E S ; Huppert, F A . / Neuropathological findings in the very old - Results from the first 101 brains of a population-based longitudinal study of dementing disorders. In: Annals of the New York Academy of Sciences. 2000 ; Vol. 903. pp. 490-496.
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T1 - Neuropathological findings in the very old - Results from the first 101 brains of a population-based longitudinal study of dementing disorders

AU - Xuereb, J H

AU - Brayne, C

AU - Dufouil, C

AU - Gertz, H

AU - Wischik, C

AU - Harrington, C

AU - Mukaetova-Ladinska, E

AU - McGee, M A

AU - O'Sullivan, A

AU - O'Connor, D

AU - Paykel, E S

AU - Huppert, F A

PY - 2000

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N2 - We report a unique Longitudinal epidemiological study of cognitive decline in the elderly population of the city of Cambridge, UK, A population sample of people aged 75 and over was surveyed between 1984-1996 (n = 2,616) and followed 2.4, 6, and 9 years later. CAMDEX diagnostic criteria were used for clinical assessment, and the neuropathological protocol (in 101 cases) was based on the CERAD method, with additional features to allow Braak staging of neurofibrillary pathology. The main findings are of the heterogeneity of lesions to be found in very old populations, and the existence of considerable overlap in the pathologies found in the demented and nondemented. It seems that white matter (ischemic) pallor an amyloid angiopathy, as well as neuritic plaques, neurofibrillary tangles and Lewy body formation are all lesions that increase the likelihood of dementia.

AB - We report a unique Longitudinal epidemiological study of cognitive decline in the elderly population of the city of Cambridge, UK, A population sample of people aged 75 and over was surveyed between 1984-1996 (n = 2,616) and followed 2.4, 6, and 9 years later. CAMDEX diagnostic criteria were used for clinical assessment, and the neuropathological protocol (in 101 cases) was based on the CERAD method, with additional features to allow Braak staging of neurofibrillary pathology. The main findings are of the heterogeneity of lesions to be found in very old populations, and the existence of considerable overlap in the pathologies found in the demented and nondemented. It seems that white matter (ischemic) pallor an amyloid angiopathy, as well as neuritic plaques, neurofibrillary tangles and Lewy body formation are all lesions that increase the likelihood of dementia.

KW - ALZHEIMERS-DISEASE

KW - PLAQUES

KW - CERAD

M3 - Article

VL - 903

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EP - 496

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -