Neuropsychologic correlates of brain white matter lesions depicted on MR images: 1921 Aberdeen Birth Cohort

S. A. Leaper, Alison Dorothy Murray, H.a. Lemmon, Roger T Staff, I. J. Deary, John Robertson Crawford, Lawrence Jeffrey Whalley

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To examine relationships between brain white matter hyperintensities depicted at magnetic resonance (MR) imaging and performance on neuropsychologic tests in community-dwelling elderly adults.

MATERIALS AND METHODS: The 1921 Aberdeen Birth Cohort is a subsample of survivors of the Scottish Mental Survey of 1932 whose mental ability was tested at 11 years of age. Ninety-five of these subjects agreed to undergo brain MR imaging, an examination of general health, and a neuropsychologic evaluation. White matter hyperintensities detected at T2-weighted MR imaging were rated by using a semi-quantitative method yielding two continuous variables: white matter lesions and periventricular lesions. Cognitive ability, including crystallized and fluid intelligence domains, was assessed with standard neuropsychologic tests.

RESULTS: Rating scores of white matter lesions were normally distributed (on a devised scale) with means of 1.14 for white matter lesions and 1.28 for periventricular lesions. Intra- and interobserver reliability coefficients for scores were high, generally above 0.7. There were significant correlations of medium effect size between the T2-weighted MR imaging-depicted white matter lesions and performance on tests of fluid-type intelligence. No significant correlation was demonstrated between white matter lesion ratings and tests of crystallized intelligence.

CONCLUSION: Lower fluid-type ("prevailing") intelligence test scores were associated with increased severity of white matter lesion ratings but not crystallized type ("remorbid") intelligence test scores. This indicates that MR imaging-depicted white matter lesions are of clinical importance.

Original languageEnglish
Pages (from-to)51-55
Number of pages4
JournalRadiology
Volume221
Issue number1
DOIs
Publication statusPublished - Oct 2001

Keywords

  • aging
  • brain, atrophy
  • brain, function
  • brain, MR
  • brain, white matter
  • VISUAL RATING-SCALES
  • RISK-FACTORS
  • SIGNAL HYPERINTENSITIES
  • CARDIOVASCULAR HEALTH
  • COGNITIVE FUNCTION
  • NORMAL INDIVIDUALS
  • BLOOD-PRESSURE
  • FOLLOW-UP
  • AGE
  • ROTTERDAM

Cite this

Neuropsychologic correlates of brain white matter lesions depicted on MR images: 1921 Aberdeen Birth Cohort. / Leaper, S. A.; Murray, Alison Dorothy; Lemmon, H.a.; Staff, Roger T; Deary, I. J.; Crawford, John Robertson; Whalley, Lawrence Jeffrey.

In: Radiology, Vol. 221, No. 1, 10.2001, p. 51-55.

Research output: Contribution to journalArticle

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AU - Leaper, S. A.

AU - Murray, Alison Dorothy

AU - Lemmon, H.a.

AU - Staff, Roger T

AU - Deary, I. J.

AU - Crawford, John Robertson

AU - Whalley, Lawrence Jeffrey

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N2 - PURPOSE: To examine relationships between brain white matter hyperintensities depicted at magnetic resonance (MR) imaging and performance on neuropsychologic tests in community-dwelling elderly adults.MATERIALS AND METHODS: The 1921 Aberdeen Birth Cohort is a subsample of survivors of the Scottish Mental Survey of 1932 whose mental ability was tested at 11 years of age. Ninety-five of these subjects agreed to undergo brain MR imaging, an examination of general health, and a neuropsychologic evaluation. White matter hyperintensities detected at T2-weighted MR imaging were rated by using a semi-quantitative method yielding two continuous variables: white matter lesions and periventricular lesions. Cognitive ability, including crystallized and fluid intelligence domains, was assessed with standard neuropsychologic tests.RESULTS: Rating scores of white matter lesions were normally distributed (on a devised scale) with means of 1.14 for white matter lesions and 1.28 for periventricular lesions. Intra- and interobserver reliability coefficients for scores were high, generally above 0.7. There were significant correlations of medium effect size between the T2-weighted MR imaging-depicted white matter lesions and performance on tests of fluid-type intelligence. No significant correlation was demonstrated between white matter lesion ratings and tests of crystallized intelligence.CONCLUSION: Lower fluid-type ("prevailing") intelligence test scores were associated with increased severity of white matter lesion ratings but not crystallized type ("remorbid") intelligence test scores. This indicates that MR imaging-depicted white matter lesions are of clinical importance.

AB - PURPOSE: To examine relationships between brain white matter hyperintensities depicted at magnetic resonance (MR) imaging and performance on neuropsychologic tests in community-dwelling elderly adults.MATERIALS AND METHODS: The 1921 Aberdeen Birth Cohort is a subsample of survivors of the Scottish Mental Survey of 1932 whose mental ability was tested at 11 years of age. Ninety-five of these subjects agreed to undergo brain MR imaging, an examination of general health, and a neuropsychologic evaluation. White matter hyperintensities detected at T2-weighted MR imaging were rated by using a semi-quantitative method yielding two continuous variables: white matter lesions and periventricular lesions. Cognitive ability, including crystallized and fluid intelligence domains, was assessed with standard neuropsychologic tests.RESULTS: Rating scores of white matter lesions were normally distributed (on a devised scale) with means of 1.14 for white matter lesions and 1.28 for periventricular lesions. Intra- and interobserver reliability coefficients for scores were high, generally above 0.7. There were significant correlations of medium effect size between the T2-weighted MR imaging-depicted white matter lesions and performance on tests of fluid-type intelligence. No significant correlation was demonstrated between white matter lesion ratings and tests of crystallized intelligence.CONCLUSION: Lower fluid-type ("prevailing") intelligence test scores were associated with increased severity of white matter lesion ratings but not crystallized type ("remorbid") intelligence test scores. This indicates that MR imaging-depicted white matter lesions are of clinical importance.

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KW - brain, atrophy

KW - brain, function

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KW - brain, white matter

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KW - SIGNAL HYPERINTENSITIES

KW - CARDIOVASCULAR HEALTH

KW - COGNITIVE FUNCTION

KW - NORMAL INDIVIDUALS

KW - BLOOD-PRESSURE

KW - FOLLOW-UP

KW - AGE

KW - ROTTERDAM

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SN - 0033-8419

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