Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain

Daniel A. Berg* (Corresponding Author), Laure Belnoue, Hongjun Song, András Simon* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

118 Citations (Scopus)

Abstract

It was long thought that no new neurons are added to the adult brain. Similarly, neurotransmitter signaling was primarily associated with communication between differentiated neurons. Both of these ideas have been challenged, and a crosstalk between neurogenesis and neurotransmitter signaling is beginning to emerge. In this Review, we discuss neurotransmitter signaling as it functions at the intersection of stem cell research and regenerative medicine, exploring how it may regulate the formation of new functional neurons and outlining interactions with other signaling pathways. We consider evolutionary and cross-species comparative aspects, and integrate available results in the context of normal physiological versus pathological conditions. We also discuss the potential role of neurotransmitters in brain size regulation and implications for cell replacement therapies.
Original languageEnglish
Pages (from-to)2548-2561
Number of pages14
JournalDevelopment (Cambridge)
Volume140
Issue number12
Early online date28 May 2013
DOIs
Publication statusPublished - 2013

Keywords

  • Adult neurogenesis
  • Homeostasis
  • Neural stem cell
  • Neurotransmitter
  • Regeneration

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