New functions for the Proprioceptive System in Skeletal Biology

Ronen Blecher, Lia Heinemann-Yerushalmi, Eran Assaraf, Nitzan Konstantin, Jens R. Chapman, Timothy C Cope, Guy S Bewick, Robert W. Banks, Elazar Zelzer (Corresponding Author)

Research output: Contribution to journalArticle

2 Citations (Scopus)
4 Downloads (Pure)

Abstract

Muscle spindles and Golgi tendon organs (GTOs) are two types of sensory receptors that respond to changes in length or tension of skeletal muscles. These mechanosensors have long been known to participate in both proprioception and stretch reflex. Here, we present recent findings implicating these organs in maintenance of spine alignment as well as in realignment of fractured bones. These discoveries have been made in several mouse lines lacking functional mechanosensors in part or completely. In both studies, the absence of functional spindles and GTOs produced a more severe phenotype than that of spindles alone. Interestingly, the spinal curve phenotype, which appeared during peripubertal development, bears resemblance to the human condition adolescent idiopathic scoliosis. This similarity may contribute to the study of the disease by offering both an animal model and a clue as to its aetiology. Moreover, it raises the possibility that impaired proprioceptive signalling may be involved in the aetiology of other conditions. Overall, these new findings expand considerably the scope of involvement of proprioception in musculoskeletal development and function.
Original languageEnglish
Article number20170327
Number of pages7
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume373
Issue number1759
Early online date24 Sep 2018
DOIs
Publication statusPublished - 5 Nov 2018

Fingerprint

proprioception
Proprioception
Mechanoreceptors
Tendons
tendons
etiology
Muscle
Musculoskeletal Development
scoliosis
sensory receptors
Phenotype
phenotype
Muscle Spindles
Biological Sciences
Stretch Reflex
Scoliosis
muscle
spine (bones)
Sensory Receptor Cells
reflexes

Keywords

  • muscle spindle
  • Golgi tendon organs
  • adolescent idiopathic scoliosis
  • proprioception
  • musculoskeleton
  • fracture repair

Cite this

Blecher, R., Heinemann-Yerushalmi, L., Assaraf, E., Konstantin, N., Chapman, J. R., Cope, T. C., ... Zelzer, E. (2018). New functions for the Proprioceptive System in Skeletal Biology. Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1759), [20170327]. https://doi.org/10.1098/rstb.2017.0327

New functions for the Proprioceptive System in Skeletal Biology. / Blecher, Ronen ; Heinemann-Yerushalmi, Lia; Assaraf, Eran; Konstantin, Nitzan ; Chapman, Jens R. ; Cope, Timothy C; Bewick, Guy S; Banks, Robert W.; Zelzer, Elazar (Corresponding Author).

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 373, No. 1759, 20170327, 05.11.2018.

Research output: Contribution to journalArticle

Blecher, R, Heinemann-Yerushalmi, L, Assaraf, E, Konstantin, N, Chapman, JR, Cope, TC, Bewick, GS, Banks, RW & Zelzer, E 2018, 'New functions for the Proprioceptive System in Skeletal Biology', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 373, no. 1759, 20170327. https://doi.org/10.1098/rstb.2017.0327
Blecher R, Heinemann-Yerushalmi L, Assaraf E, Konstantin N, Chapman JR, Cope TC et al. New functions for the Proprioceptive System in Skeletal Biology. Philosophical Transactions of the Royal Society B: Biological Sciences. 2018 Nov 5;373(1759). 20170327. https://doi.org/10.1098/rstb.2017.0327
Blecher, Ronen ; Heinemann-Yerushalmi, Lia ; Assaraf, Eran ; Konstantin, Nitzan ; Chapman, Jens R. ; Cope, Timothy C ; Bewick, Guy S ; Banks, Robert W. ; Zelzer, Elazar. / New functions for the Proprioceptive System in Skeletal Biology. In: Philosophical Transactions of the Royal Society B: Biological Sciences. 2018 ; Vol. 373, No. 1759.
@article{39a74b2c9614451cb8d089fb96e92b9d,
title = "New functions for the Proprioceptive System in Skeletal Biology",
abstract = "Muscle spindles and Golgi tendon organs (GTOs) are two types of sensory receptors that respond to changes in length or tension of skeletal muscles. These mechanosensors have long been known to participate in both proprioception and stretch reflex. Here, we present recent findings implicating these organs in maintenance of spine alignment as well as in realignment of fractured bones. These discoveries have been made in several mouse lines lacking functional mechanosensors in part or completely. In both studies, the absence of functional spindles and GTOs produced a more severe phenotype than that of spindles alone. Interestingly, the spinal curve phenotype, which appeared during peripubertal development, bears resemblance to the human condition adolescent idiopathic scoliosis. This similarity may contribute to the study of the disease by offering both an animal model and a clue as to its aetiology. Moreover, it raises the possibility that impaired proprioceptive signalling may be involved in the aetiology of other conditions. Overall, these new findings expand considerably the scope of involvement of proprioception in musculoskeletal development and function.",
keywords = "muscle spindle, Golgi tendon organs, adolescent idiopathic scoliosis, proprioception, musculoskeleton, fracture repair",
author = "Ronen Blecher and Lia Heinemann-Yerushalmi and Eran Assaraf and Nitzan Konstantin and Chapman, {Jens R.} and Cope, {Timothy C} and Bewick, {Guy S} and Banks, {Robert W.} and Elazar Zelzer",
note = "This review was supported by grants from the Israel Science Foundation MORASHA Biomedical Research Program in Neurodegenerative Diseases, Genetic Disorders and Metabolic Diseases (no. 2147/17) and from the estate of Bernard Bishin for the WIS-Clalit Program (to E.Z.).",
year = "2018",
month = "11",
day = "5",
doi = "10.1098/rstb.2017.0327",
language = "English",
volume = "373",
journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",
issn = "0962-8436",
publisher = "ROYAL SOC CHEMISTRY",
number = "1759",

}

TY - JOUR

T1 - New functions for the Proprioceptive System in Skeletal Biology

AU - Blecher, Ronen

AU - Heinemann-Yerushalmi, Lia

AU - Assaraf, Eran

AU - Konstantin, Nitzan

AU - Chapman, Jens R.

AU - Cope, Timothy C

AU - Bewick, Guy S

AU - Banks, Robert W.

AU - Zelzer, Elazar

N1 - This review was supported by grants from the Israel Science Foundation MORASHA Biomedical Research Program in Neurodegenerative Diseases, Genetic Disorders and Metabolic Diseases (no. 2147/17) and from the estate of Bernard Bishin for the WIS-Clalit Program (to E.Z.).

PY - 2018/11/5

Y1 - 2018/11/5

N2 - Muscle spindles and Golgi tendon organs (GTOs) are two types of sensory receptors that respond to changes in length or tension of skeletal muscles. These mechanosensors have long been known to participate in both proprioception and stretch reflex. Here, we present recent findings implicating these organs in maintenance of spine alignment as well as in realignment of fractured bones. These discoveries have been made in several mouse lines lacking functional mechanosensors in part or completely. In both studies, the absence of functional spindles and GTOs produced a more severe phenotype than that of spindles alone. Interestingly, the spinal curve phenotype, which appeared during peripubertal development, bears resemblance to the human condition adolescent idiopathic scoliosis. This similarity may contribute to the study of the disease by offering both an animal model and a clue as to its aetiology. Moreover, it raises the possibility that impaired proprioceptive signalling may be involved in the aetiology of other conditions. Overall, these new findings expand considerably the scope of involvement of proprioception in musculoskeletal development and function.

AB - Muscle spindles and Golgi tendon organs (GTOs) are two types of sensory receptors that respond to changes in length or tension of skeletal muscles. These mechanosensors have long been known to participate in both proprioception and stretch reflex. Here, we present recent findings implicating these organs in maintenance of spine alignment as well as in realignment of fractured bones. These discoveries have been made in several mouse lines lacking functional mechanosensors in part or completely. In both studies, the absence of functional spindles and GTOs produced a more severe phenotype than that of spindles alone. Interestingly, the spinal curve phenotype, which appeared during peripubertal development, bears resemblance to the human condition adolescent idiopathic scoliosis. This similarity may contribute to the study of the disease by offering both an animal model and a clue as to its aetiology. Moreover, it raises the possibility that impaired proprioceptive signalling may be involved in the aetiology of other conditions. Overall, these new findings expand considerably the scope of involvement of proprioception in musculoskeletal development and function.

KW - muscle spindle

KW - Golgi tendon organs

KW - adolescent idiopathic scoliosis

KW - proprioception

KW - musculoskeleton

KW - fracture repair

U2 - 10.1098/rstb.2017.0327

DO - 10.1098/rstb.2017.0327

M3 - Article

VL - 373

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

SN - 0962-8436

IS - 1759

M1 - 20170327

ER -