New insights into the relationship between conversion and enantioselectivity for the asymmetric hydrogenation of alkyl pyruvate

Xiabao Li, Richard Peter Kerwin Wells, Peter B Wells, G J Hutchings

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21 Citations (Scopus)

Abstract

The initial transient period in the enantioselective hydrogenation of alkyl pyruvate esters is probed using the sequential reactions of ethyl and methyl pyruvate. The reaction of methyl pyruvate, subsequent to the hydrogenation of ethyl pyruvate, led to a higher e.e. when compared to the coreaction of these reactants, or prehydrogenation with methyl pyruvate followed by reaction of ethyl pyruvate. The initial transient effect, in which e.e. increases with conversion, is observed in both periods of the sequential reaction and the origin of this effect is discussed. (C) 2003 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)653-656
Number of pages4
JournalJournal of Catalysis
Volume221
Issue number2
Early online date3 Dec 2003
DOIs
Publication statusPublished - 25 Apr 2004

Keywords

  • enantioselective hydrogenation of alkyl pyruvates
  • cinchonidine-modified Pt/Al2O3 catalysts
  • initial transient period
  • enantioselective hydrogenation
  • ethyl pyruvate
  • PD

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