New nodulopeptins from Nodularia spumigena KAC 66

Marc Schumacher, Neil Wilson, Jioji N. Tabudravu, Christine Edwards, Linda A. Lawton, Cherie Motti, Anthony D. Wright, Marc Diederich, Marcel Jaspars*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Investigation of aqueous methanol extracts of the cyanobacterium Nodularia spumigena KAC 66 led to the isolation of the nodulopeptins 899, 901 and 917. The chemical structures were determined using high-resolution NMR and MS-data. The stereochemistry of the amino-acid residues was realized by LC-MS analysis using Marfey's reagent. The bioactivity of the novel compounds was determined.

Original languageEnglish
Pages (from-to)1622-1628
Number of pages7
JournalTetrahedron
Volume68
Issue number5
Early online date26 Nov 2011
DOIs
Publication statusPublished - 4 Feb 2012

Keywords

  • Cyanobacteria
  • NF-κB
  • Peptides
  • Polypeptides
  • Spectroscopy
  • Structure determination

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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  • Cite this

    Schumacher, M., Wilson, N., Tabudravu, J. N., Edwards, C., Lawton, L. A., Motti, C., Wright, A. D., Diederich, M., & Jaspars, M. (2012). New nodulopeptins from Nodularia spumigena KAC 66. Tetrahedron, 68(5), 1622-1628. https://doi.org/10.1016/j.tet.2011.11.056