New nodulopeptins from Nodularia spumigena KAC 66

Marc Schumacher, Neil Wilson, Jioji N. Tabudravu, Christine Edwards, Linda A. Lawton, Cherie Motti, Anthony D. Wright, Marc Diederich, Marcel Jaspars*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Investigation of aqueous methanol extracts of the cyanobacterium Nodularia spumigena KAC 66 led to the isolation of the nodulopeptins 899, 901 and 917. The chemical structures were determined using high-resolution NMR and MS-data. The stereochemistry of the amino-acid residues was realized by LC-MS analysis using Marfey's reagent. The bioactivity of the novel compounds was determined.

Original languageEnglish
Pages (from-to)1622-1628
Number of pages7
JournalTetrahedron
Volume68
Issue number5
Early online date26 Nov 2011
DOIs
Publication statusPublished - 4 Feb 2012

Fingerprint

Nodularia
Stereochemistry
Cyanobacteria
Bioactivity
Methanol
Nuclear magnetic resonance
Amino Acids
Marfey's reagent

Keywords

  • Cyanobacteria
  • NF-κB
  • Peptides
  • Polypeptides
  • Spectroscopy
  • Structure determination

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Schumacher, M., Wilson, N., Tabudravu, J. N., Edwards, C., Lawton, L. A., Motti, C., ... Jaspars, M. (2012). New nodulopeptins from Nodularia spumigena KAC 66. Tetrahedron, 68(5), 1622-1628. https://doi.org/10.1016/j.tet.2011.11.056

New nodulopeptins from Nodularia spumigena KAC 66. / Schumacher, Marc; Wilson, Neil; Tabudravu, Jioji N.; Edwards, Christine; Lawton, Linda A.; Motti, Cherie; Wright, Anthony D.; Diederich, Marc; Jaspars, Marcel.

In: Tetrahedron, Vol. 68, No. 5, 04.02.2012, p. 1622-1628.

Research output: Contribution to journalArticle

Schumacher, M, Wilson, N, Tabudravu, JN, Edwards, C, Lawton, LA, Motti, C, Wright, AD, Diederich, M & Jaspars, M 2012, 'New nodulopeptins from Nodularia spumigena KAC 66', Tetrahedron, vol. 68, no. 5, pp. 1622-1628. https://doi.org/10.1016/j.tet.2011.11.056
Schumacher M, Wilson N, Tabudravu JN, Edwards C, Lawton LA, Motti C et al. New nodulopeptins from Nodularia spumigena KAC 66. Tetrahedron. 2012 Feb 4;68(5):1622-1628. https://doi.org/10.1016/j.tet.2011.11.056
Schumacher, Marc ; Wilson, Neil ; Tabudravu, Jioji N. ; Edwards, Christine ; Lawton, Linda A. ; Motti, Cherie ; Wright, Anthony D. ; Diederich, Marc ; Jaspars, Marcel. / New nodulopeptins from Nodularia spumigena KAC 66. In: Tetrahedron. 2012 ; Vol. 68, No. 5. pp. 1622-1628.
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