New nodulopeptins from Nodularia spumigena KAC 66

Marc Schumacher; Neil Wilson; Jioji N. Tabudravu; Christine Edwards; Linda A. Lawton; Cherie Motti; Anthony D. Wright; Marc Diederich; Marcel Jaspars

doi:10.1016/j.tet.2011.11.056

New nodulopeptins from Nodularia spumigena KAC 66

Marc Schumacher, Neil Wilson, Jioji N. Tabudravu, Christine Edwards, Linda A. Lawton, Cherie Motti, Anthony D. Wright, Marc Diederich, Marcel Jaspars^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Investigation of aqueous methanol extracts of the cyanobacterium Nodularia spumigena KAC 66 led to the isolation of the nodulopeptins 899, 901 and 917. The chemical structures were determined using high-resolution NMR and MS-data. The stereochemistry of the amino-acid residues was realized by LC-MS analysis using Marfey's reagent. The bioactivity of the novel compounds was determined.

Original language	English
Pages (from-to)	1622-1628
Number of pages	7
Journal	Tetrahedron
Volume	68
Issue number	5
Early online date	26 Nov 2011
DOIs	https://doi.org/10.1016/j.tet.2011.11.056
Publication status	Published - 4 Feb 2012

Bibliographical note

Acknowledgements
M.S. was supported by research grant BFR 06/016 of the Ministère de la Culture, de l’Enseignement supérieur et de la Recherche (Grand-Duchy of Luxembourg). Research at the Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC) is financially supported by the “Recherche Cancer et Sang foundation”, the “Recherches Scientifiques Luxembourg” association, the “Een Haerz fir kriibskrank Kanner” association, the “Action Lions Vaincre le Cancer” association, and by Télévie Luxembourg. We would like to thank Enzo Life Sciences, Lausen, Switzerland for their support. We thank Sharon Kelly for measurement of the CD spectrum. We thank Rut Jordana for the IR measurement

Keywords

Cyanobacteria
NF-κB
Peptides
Polypeptides
Spectroscopy
Structure determination

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abstract = "Investigation of aqueous methanol extracts of the cyanobacterium Nodularia spumigena KAC 66 led to the isolation of the nodulopeptins 899, 901 and 917. The chemical structures were determined using high-resolution NMR and MS-data. The stereochemistry of the amino-acid residues was realized by LC-MS analysis using Marfey's reagent. The bioactivity of the novel compounds was determined.",

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note = "Acknowledgements M.S. was supported by research grant BFR 06/016 of the Minist{\`e}re de la Culture, de l{\textquoteright}Enseignement sup{\'e}rieur et de la Recherche (Grand-Duchy of Luxembourg). Research at the Laboratoire de Biologie Mol{\'e}culaire et Cellulaire du Cancer (LBMCC) is financially supported by the “Recherche Cancer et Sang foundation”, the “Recherches Scientifiques Luxembourg” association, the “Een Haerz fir kriibskrank Kanner” association, the “Action Lions Vaincre le Cancer” association, and by T{\'e}l{\'e}vie Luxembourg. We would like to thank Enzo Life Sciences, Lausen, Switzerland for their support. We thank Sharon Kelly for measurement of the CD spectrum. We thank Rut Jordana for the IR measurement",

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New nodulopeptins from Nodularia spumigena KAC 66

Abstract

Bibliographical note

Keywords

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