NF-kappa B-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus

Florence Folmer, William T. A. Harrison, Jicji N. Tabudravu, Marcel Jaspars, William Aalbersberg, Klaus Feussner, Anthony D. Wright, Mario Dicato, Marc Diederich

Research output: Contribution to journalArticle

35 Citations (Scopus)


The two naphthopyrones 6-methoxycomaparvin (1) and 6-methoxycomaparvin 5-methyl ether (2) were isolated from a bioactive methanol-soluble extract of the Fijian echinoderm Comanthus parvicirrus. Their structures were assigned on the basis of spectroscopic methods. X-ray diffraction analysis was used to confirm the structure of 1. Both compounds were tested for their potential to inhibit the activation of the transcription factor NF-kappa B, which plays an important role in cancer development and inflammation, and the mechanism of action of the two compounds was investigated. Both naphthopyrones 1 and 2 completely inhibit TNF-alpha-induced NF-kappa B activation at a concentration of 300 mu M by inhibiting the enzymatic activity of the kinase IKK beta.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalJournal of Natural Products
Issue number1
Early online date19 Dec 2007
Publication statusPublished - Jan 2008


  • marine animals
  • drug development
  • cancer
  • pigments
  • activation
  • emodin
  • mechanisms
  • expression
  • prevention
  • crinoids


Dive into the research topics of 'NF-kappa B-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus'. Together they form a unique fingerprint.

Cite this