NF-kappa B-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus

Florence Folmer, William T. A. Harrison, Jicji N. Tabudravu, Marcel Jaspars, William Aalbersberg, Klaus Feussner, Anthony D. Wright, Mario Dicato, Marc Diederich

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28 Citations (Scopus)

Abstract

The two naphthopyrones 6-methoxycomaparvin (1) and 6-methoxycomaparvin 5-methyl ether (2) were isolated from a bioactive methanol-soluble extract of the Fijian echinoderm Comanthus parvicirrus. Their structures were assigned on the basis of spectroscopic methods. X-ray diffraction analysis was used to confirm the structure of 1. Both compounds were tested for their potential to inhibit the activation of the transcription factor NF-kappa B, which plays an important role in cancer development and inflammation, and the mechanism of action of the two compounds was investigated. Both naphthopyrones 1 and 2 completely inhibit TNF-alpha-induced NF-kappa B activation at a concentration of 300 mu M by inhibiting the enzymatic activity of the kinase IKK beta.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalJournal of Natural Products
Volume71
Issue number1
Early online date19 Dec 2007
DOIs
Publication statusPublished - Jan 2008

Keywords

  • marine animals
  • drug development
  • cancer
  • pigments
  • activation
  • emodin
  • mechanisms
  • expression
  • prevention
  • crinoids

Cite this

Folmer, F., Harrison, W. T. A., Tabudravu, J. N., Jaspars, M., Aalbersberg, W., Feussner, K., Wright, A. D., Dicato, M., & Diederich, M. (2008). NF-kappa B-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus. Journal of Natural Products, 71(1), 106-111. https://doi.org/10.1021/np070290y