TY - JOUR
T1 - Nitric oxide in a nutshell
T2 - Genetics, physiology and pathology
AU - Galley, H. F.
AU - Webster, N. R.
PY - 1998/8/1
Y1 - 1998/8/1
N2 - The idea that nitric oxide gas, known from undergraduate chemistry to be a toxic by-product of car exhausts and cigarettes, and the scourge of anaesthetists as a contaminant of nitrous oxide cylinders, could be a biological mediator, was unthinkable 15 years ago. However, in 1987, it was shown that the elusive endothelium-derived relaxing factor was indeed nitric oxide, produced by mammalian cells, with roles in blood pressure regulation, neurotransmission, immunity and cardiovascular function.
AB - The idea that nitric oxide gas, known from undergraduate chemistry to be a toxic by-product of car exhausts and cigarettes, and the scourge of anaesthetists as a contaminant of nitrous oxide cylinders, could be a biological mediator, was unthinkable 15 years ago. However, in 1987, it was shown that the elusive endothelium-derived relaxing factor was indeed nitric oxide, produced by mammalian cells, with roles in blood pressure regulation, neurotransmission, immunity and cardiovascular function.
UR - http://www.scopus.com/inward/record.url?scp=0032432413&partnerID=8YFLogxK
U2 - 10.1016/S0953-7112(98)80057-4
DO - 10.1016/S0953-7112(98)80057-4
M3 - Article
AN - SCOPUS:0032432413
SN - 0953-7112
VL - 9
SP - 209
EP - 213
JO - Current Anaesthesia and Critical Care
JF - Current Anaesthesia and Critical Care
IS - 4
ER -