Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells

Grenville M Oades, Siddhika G Senaratne, Ian A Clarke, Roger S Kirby, Kay W Colston

    Research output: Contribution to journalArticlepeer-review

    129 Citations (Scopus)

    Abstract

    Metastasis to bone is an important cause of morbidity in advanced prostate cancer. Despite the typically sclerotic nature of prostatic bone metastases osteolysis has a significant role in the pathogenesis of this disease. The nitrogen containing bisphosphonates (N-BPs), such as pamidronate and zoledronic acid, have greatly enhanced potency for inhibiting bone resorption and inducing apoptosis in osteoclasts. We investigated the effects of N-BPs on prostate cancer cells.
    Original languageEnglish
    Pages (from-to)246-52
    Number of pages7
    JournalJournal of Urology
    Volume170
    Issue number1
    DOIs
    Publication statusPublished - 2003

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