Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells

Grenville M Oades, Siddhika G Senaratne, Ian A Clarke, Roger S Kirby, Kay W Colston

    Research output: Contribution to journalArticle

    128 Citations (Scopus)

    Abstract

    Metastasis to bone is an important cause of morbidity in advanced prostate cancer. Despite the typically sclerotic nature of prostatic bone metastases osteolysis has a significant role in the pathogenesis of this disease. The nitrogen containing bisphosphonates (N-BPs), such as pamidronate and zoledronic acid, have greatly enhanced potency for inhibiting bone resorption and inducing apoptosis in osteoclasts. We investigated the effects of N-BPs on prostate cancer cells.
    Original languageEnglish
    Pages (from-to)246-52
    Number of pages7
    JournalJournal of Urology
    Volume170
    Issue number1
    DOIs
    Publication statusPublished - 2003

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