Nivetetracyclates A and B: Novel Compounds Isolated from Streptomyces niveus

Caixia Chen; Xueting Liu; Wael M. Abdel-Mageed; Hui Guo; Weiyuan Hou; Marcel Jaspars; Li Li; Feng Xie; Biao Ren; Qian Wang; Huanqin Dai; Fuhang Song; Lixin Zhang

doi:10.1021/ol4027733

Nivetetracyclates A and B: Novel Compounds Isolated from Streptomyces niveus

Caixia Chen, Xueting Liu, Wael M. Abdel-Mageed, Hui Guo, Weiyuan Hou, Marcel Jaspars, Li Li, Feng Xie, Biao Ren, Qian Wang, Huanqin Dai, Fuhang Song^*, Lixin Zhang

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Letter › peer-review

7 Citations (Scopus)

Abstract

A high-throughput screening of a microbial natural product library led to the discovery of two novel compounds named nivetetracyclates A and B (1 and 2), which were produced by Streptomyces niveus designated as LS2151. The backbone of the compounds contains a hydrotetracyclate not previously reported from a natural source. The structures of the compounds were elucidated by spectroscopic methods. The nivetetracyclates exhibited activity against human HeLa cells.

Original language	English
Pages (from-to)	5762-5765
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	22
Early online date	25 Oct 2013
DOIs	https://doi.org/10.1021/ol4027733
Publication status	Published - 15 Nov 2013

Bibliographical note

Acknowledgement:
This work is supported in part by the National Program on Key Basic Research Project(973 program 2013CB734000), The National Natural Science Foundation of china (81102356, 30901849, 81102369), and the General and Special Program of China Postdoctoral Science Foundation (20110490622, 2012T50149). L. Zhang is an Awardee of the National Distinguished Young scholar Program in China.

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title = "Nivetetracyclates A and B: Novel Compounds Isolated from Streptomyces niveus",

abstract = "A high-throughput screening of a microbial natural product library led to the discovery of two novel compounds named nivetetracyclates A and B (1 and 2), which were produced by Streptomyces niveus designated as LS2151. The backbone of the compounds contains a hydrotetracyclate not previously reported from a natural source. The structures of the compounds were elucidated by spectroscopic methods. The nivetetracyclates exhibited activity against human HeLa cells.",

author = "Caixia Chen and Xueting Liu and Abdel-Mageed, {Wael M.} and Hui Guo and Weiyuan Hou and Marcel Jaspars and Li Li and Feng Xie and Biao Ren and Qian Wang and Huanqin Dai and Fuhang Song and Lixin Zhang",

note = "Acknowledgement: This work is supported in part by the National Program on Key Basic Research Project(973 program 2013CB734000), The National Natural Science Foundation of china (81102356, 30901849, 81102369), and the General and Special Program of China Postdoctoral Science Foundation (20110490622, 2012T50149). L. Zhang is an Awardee of the National Distinguished Young scholar Program in China.",

year = "2013",

month = nov,

day = "15",

doi = "10.1021/ol4027733",

language = "English",

volume = "15",

pages = "5762--5765",

journal = "Organic Letters",

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TY - JOUR

T1 - Nivetetracyclates A and B

T2 - Novel Compounds Isolated from Streptomyces niveus

AU - Chen, Caixia

AU - Liu, Xueting

AU - Abdel-Mageed, Wael M.

AU - Guo, Hui

AU - Hou, Weiyuan

AU - Jaspars, Marcel

AU - Li, Li

AU - Xie, Feng

AU - Ren, Biao

AU - Wang, Qian

AU - Dai, Huanqin

AU - Song, Fuhang

AU - Zhang, Lixin

N1 - Acknowledgement: This work is supported in part by the National Program on Key Basic Research Project(973 program 2013CB734000), The National Natural Science Foundation of china (81102356, 30901849, 81102369), and the General and Special Program of China Postdoctoral Science Foundation (20110490622, 2012T50149). L. Zhang is an Awardee of the National Distinguished Young scholar Program in China.

PY - 2013/11/15

Y1 - 2013/11/15

N2 - A high-throughput screening of a microbial natural product library led to the discovery of two novel compounds named nivetetracyclates A and B (1 and 2), which were produced by Streptomyces niveus designated as LS2151. The backbone of the compounds contains a hydrotetracyclate not previously reported from a natural source. The structures of the compounds were elucidated by spectroscopic methods. The nivetetracyclates exhibited activity against human HeLa cells.

AB - A high-throughput screening of a microbial natural product library led to the discovery of two novel compounds named nivetetracyclates A and B (1 and 2), which were produced by Streptomyces niveus designated as LS2151. The backbone of the compounds contains a hydrotetracyclate not previously reported from a natural source. The structures of the compounds were elucidated by spectroscopic methods. The nivetetracyclates exhibited activity against human HeLa cells.

U2 - 10.1021/ol4027733

DO - 10.1021/ol4027733

M3 - Letter

SN - 1523-7060

VL - 15

SP - 5762

EP - 5765

JO - Organic Letters

JF - Organic Letters

IS - 22

ER -

Nivetetracyclates A and B: Novel Compounds Isolated from Streptomyces niveus

Abstract

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