Nivetetracyclates A and B: Novel Compounds Isolated from Streptomyces niveus

Caixia Chen, Xueting Liu, Wael M. Abdel-Mageed, Hui Guo, Weiyuan Hou, Marcel Jaspars, Li Li, Feng Xie, Biao Ren, Qian Wang, Huanqin Dai, Fuhang Song*, Lixin Zhang

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

6 Citations (Scopus)


A high-throughput screening of a microbial natural product library led to the discovery of two novel compounds named nivetetracyclates A and B (1 and 2), which were produced by Streptomyces niveus designated as LS2151. The backbone of the compounds contains a hydrotetracyclate not previously reported from a natural source. The structures of the compounds were elucidated by spectroscopic methods. The nivetetracyclates exhibited activity against human HeLa cells.

Original languageEnglish
Pages (from-to)5762-5765
Number of pages4
JournalOrganic Letters
Issue number22
Early online date25 Oct 2013
Publication statusPublished - 15 Nov 2013


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