No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke

M J MacLeod, M T Dahiyat, A Cumming, D Meiklejohn, D Shaw, D St Clair

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke, We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.

Original languageEnglish
Pages (from-to)418-420
Number of pages3
JournalNeurology
Volume53
Publication statusPublished - 1999

Keywords

  • NITRIC-OXIDE SYNTHASE
  • RAT MODEL
  • DISEASE

Cite this

No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke. / MacLeod, M J ; Dahiyat, M T ; Cumming, A ; Meiklejohn, D ; Shaw, D ; St Clair, D .

In: Neurology, Vol. 53, 1999, p. 418-420.

Research output: Contribution to journalArticle

MacLeod, M J ; Dahiyat, M T ; Cumming, A ; Meiklejohn, D ; Shaw, D ; St Clair, D . / No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke. In: Neurology. 1999 ; Vol. 53. pp. 418-420.
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AU - St Clair, D

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