No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke

M J MacLeod, M T Dahiyat, A Cumming, D Meiklejohn, D Shaw, D St Clair

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Abstract

Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke, We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.

Original languageEnglish
Pages (from-to)418-420
Number of pages3
JournalNeurology
Volume53
Publication statusPublished - 1999

Keywords

  • NITRIC-OXIDE SYNTHASE
  • RAT MODEL
  • DISEASE

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