Abstract
Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke, We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.
Original language | English |
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Pages (from-to) | 418-420 |
Number of pages | 3 |
Journal | Neurology |
Volume | 53 |
Publication status | Published - 1999 |
Keywords
- NITRIC-OXIDE SYNTHASE
- RAT MODEL
- DISEASE