No association between the PPARG gene and schizophrenia in a British population

Aditi Mathur, Matthew H Law, Tayebeh Hamzehloei, Ian L Megson, Duncan J Shaw, Jun Wei

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

It has consistently been reported that patients with schizophrenia have an increased risk of type-2 diabetes. To investigate a genetic link between these two diseases, the combined effects of the PLA2G4A, PTGS2 and PPARG genes were tested among 221 British nuclear families consisting of fathers, mothers and affected offspring with schizophrenia. A total of 10 single nucleotide polymorphisms (SNPs) were tested and the likelihood-based association analysis for nuclear families was used to analyse the genotyping data. Eight SNPs detected across the PPARG gene did not show allelic association with schizophrenia; a weak association was detected at rs2745557 in the PTGS2 locus (chi2=4.19, p=0.041) and rs10798059 in the PLA2G4A locus (chi2=4.28, p=0.039) but these associations did not survive after 10,000 permutations to correct the p-value (global p=0.246). The gene-gene interaction test did not show any evidence of either cis-phase interactions for the PLA2G4A and PTGS2 combinations or a trans-phase interaction for the PLA2G4A and PPARG combinations. The PPARG gene has been reported to be strongly associated with type-2 diabetes, but the present study did not support the hypothesis that the PPARG gene may also play an important role in the development of schizophrenia.
Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume81
Issue number4
Early online date26 Jun 2009
DOIs
Publication statusPublished - Oct 2009

Fingerprint

Schizophrenia
Genes
Cyclooxygenase 2
Population
Medical problems
Polymorphism
Nuclear Family
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
Nucleotides
Fathers
Mothers

Keywords

  • adult
  • cyclooxygenase 2
  • female
  • genotype
  • Great Britain
  • group IV phospholipases A2
  • humans
  • male
  • PPAR gamma
  • polymorphism, single nucleotide
  • schizophrenia
  • PPARG
  • PLA2G4A
  • PTGS2
  • type-2 diabetes

Cite this

No association between the PPARG gene and schizophrenia in a British population. / Mathur, Aditi; Law, Matthew H; Hamzehloei, Tayebeh; Megson, Ian L; Shaw, Duncan J; Wei, Jun.

In: Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 81, No. 4, 10.2009, p. 273-277.

Research output: Contribution to journalArticle

Mathur, Aditi ; Law, Matthew H ; Hamzehloei, Tayebeh ; Megson, Ian L ; Shaw, Duncan J ; Wei, Jun. / No association between the PPARG gene and schizophrenia in a British population. In: Prostaglandins, Leukotrienes and Essential Fatty Acids. 2009 ; Vol. 81, No. 4. pp. 273-277.
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AB - It has consistently been reported that patients with schizophrenia have an increased risk of type-2 diabetes. To investigate a genetic link between these two diseases, the combined effects of the PLA2G4A, PTGS2 and PPARG genes were tested among 221 British nuclear families consisting of fathers, mothers and affected offspring with schizophrenia. A total of 10 single nucleotide polymorphisms (SNPs) were tested and the likelihood-based association analysis for nuclear families was used to analyse the genotyping data. Eight SNPs detected across the PPARG gene did not show allelic association with schizophrenia; a weak association was detected at rs2745557 in the PTGS2 locus (chi2=4.19, p=0.041) and rs10798059 in the PLA2G4A locus (chi2=4.28, p=0.039) but these associations did not survive after 10,000 permutations to correct the p-value (global p=0.246). The gene-gene interaction test did not show any evidence of either cis-phase interactions for the PLA2G4A and PTGS2 combinations or a trans-phase interaction for the PLA2G4A and PPARG combinations. The PPARG gene has been reported to be strongly associated with type-2 diabetes, but the present study did not support the hypothesis that the PPARG gene may also play an important role in the development of schizophrenia.

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