Non-mnestic cognitive function in the scopolamine model of Alzheimer's disease

M C Obonsawin, A Graeme W Robertson, John Robertson Crawford, C Perera, Susan Walker, L Blackmore, Fiona Lindsay Mary Parker, J A O Besson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The contribution of cholinergic dysfunction to the non-mnestic cognitive impairments associated with senile dementia of the Alzheimer type (SDAT) was investigated. Scopolamine (0.5 mg) was administered intravenously to 12 healthy individuals, and their performance on selected subtests of the Wechsler Adult Intelligence Scale Revised (WAIS-R), and on additional non-mnestic neuropsychological tests were compared to that of 12 healthy control participants. The results demonstrate that scopolamine does impair performance on components of the WAIS-R, but that the Fuld WAIS-R profile does not have a cholinergic basis. Scopolamine did not impair performance on verbal fluency, the Token Test, Judgment of:line Orientation, finger tapping, the Modified Card Sorting Test, or the Mini-Mental State Examination. The results do not support the hypothesis that the cholinergic system contributes to the non-mnestic impairments in SDAT. (C) 1998 John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)439-449
Number of pages11
JournalHuman Psychopharmacology-Clinical and Experimental
Volume13
Issue number6
DOIs
Publication statusPublished - Aug 1998

Keywords

  • scopolamine
  • muscarinic blockade
  • senile dementia of the Alzheimer's type
  • Fuld profile
  • CARD SORTING TEST
  • R FULD PROFILE
  • CHOLINERGIC HYPOTHESIS
  • HUMAN-MEMORY
  • NUCLEUS BASALIS
  • VERBAL FLUENCY
  • DEMENTIA
  • TACRINE
  • DYSFUNCTION
  • SENSITIVITY

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