Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer

J. C. Wilson; L. J. Murray; C. M. Hughes; A. Black; L. A. Anderson

doi:10.1038/bjc.2013.73

Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer

J. C. Wilson^*, L. J. Murray, C. M. Hughes, A. Black, L. A. Anderson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background:

Evidence for non-steroidal anti-inflammatory drugs (NSAIDs) preventing head and neck cancer (HNC) is inconclusive; however, there is some suggestion that aspirin may exert a protective effect.

Methods:

Using data from the United States National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined the association between aspirin and ibuprofen use and HNC.

Results:

Regular aspirin use was associated with a significant 22% reduction in HNC risk. No association was observed with regular ibuprofen use.

Conclusion:

Aspirin may have potential as a chemopreventive agent for HNC, but further investigation is warranted.

Original language	English
Pages (from-to)	1178-1181
Number of pages	4
Journal	British Journal of Cancer
Volume	108
Issue number	5
Early online date	28 Feb 2013
DOIs	https://doi.org/10.1038/bjc.2013.73
Publication status	Published - 19 Mar 2013

Keywords

aspirin
cohort study
head and neck cancer
ibuprofen

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Wilson_et_al_BJC_NonSteroidalAntiInflammatory_VoR
© 2013 Cancer Research UK. All rights reserved 0007 – 0920/13. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
Final published version, 151 KBLicence: CC BY-NC-SA

Cite this

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title = "Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer",

abstract = "Background:Evidence for non-steroidal anti-inflammatory drugs (NSAIDs) preventing head and neck cancer (HNC) is inconclusive; however, there is some suggestion that aspirin may exert a protective effect.Methods:Using data from the United States National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined the association between aspirin and ibuprofen use and HNC.Results:Regular aspirin use was associated with a significant 22% reduction in HNC risk. No association was observed with regular ibuprofen use.Conclusion:Aspirin may have potential as a chemopreventive agent for HNC, but further investigation is warranted.",

keywords = "aspirin, cohort study, head and neck cancer, ibuprofen",

author = "Wilson, {J. C.} and Murray, {L. J.} and Hughes, {C. M.} and A. Black and Anderson, {L. A.}",

note = "Acknowledgements This research was supported by contracts from the Division of Cancer Prevention, National Cancer Institute; NIH, DHHS. We thank Drs Christine Berg and Philip Prorok, Division of Cancer Prevention, National Cancer Institute, the Screening Centre investigators and staff of the PLCO Cancer Screening Trial; Mr Tom Riley and staff, Information Management Services, Inc.; Ms Barbara O{\textquoteright}Brien and staff, Westat, Inc. Most importantly, we acknowledge the study participants for their contributions to making this study possible.",

year = "2013",

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doi = "10.1038/bjc.2013.73",

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AU - Wilson, J. C.

AU - Murray, L. J.

AU - Hughes, C. M.

AU - Black, A.

AU - Anderson, L. A.

N1 - Acknowledgements This research was supported by contracts from the Division of Cancer Prevention, National Cancer Institute; NIH, DHHS. We thank Drs Christine Berg and Philip Prorok, Division of Cancer Prevention, National Cancer Institute, the Screening Centre investigators and staff of the PLCO Cancer Screening Trial; Mr Tom Riley and staff, Information Management Services, Inc.; Ms Barbara O’Brien and staff, Westat, Inc. Most importantly, we acknowledge the study participants for their contributions to making this study possible.

PY - 2013/3/19

Y1 - 2013/3/19

N2 - Background:Evidence for non-steroidal anti-inflammatory drugs (NSAIDs) preventing head and neck cancer (HNC) is inconclusive; however, there is some suggestion that aspirin may exert a protective effect.Methods:Using data from the United States National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined the association between aspirin and ibuprofen use and HNC.Results:Regular aspirin use was associated with a significant 22% reduction in HNC risk. No association was observed with regular ibuprofen use.Conclusion:Aspirin may have potential as a chemopreventive agent for HNC, but further investigation is warranted.

AB - Background:Evidence for non-steroidal anti-inflammatory drugs (NSAIDs) preventing head and neck cancer (HNC) is inconclusive; however, there is some suggestion that aspirin may exert a protective effect.Methods:Using data from the United States National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined the association between aspirin and ibuprofen use and HNC.Results:Regular aspirin use was associated with a significant 22% reduction in HNC risk. No association was observed with regular ibuprofen use.Conclusion:Aspirin may have potential as a chemopreventive agent for HNC, but further investigation is warranted.

KW - aspirin

KW - cohort study

KW - head and neck cancer

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Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer

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Keywords

UN SDGs

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