Nonmuscle myosins IIA and IIB are present in adult motor nerve terminals

Laura J Vega-Riveroll, Steven R Wylie, Paul T Loughna, Simon H Parson, Peter D Chantler

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Throughout life, neuromuscular junctions undergo dynamic changes, remodelling occurring through extension and withdrawal of motor nerve terminals in conjunction with changes in the distribution of acetylcholine receptors at the muscle endplate. However, relatively little is known about the fundamental processes by which nerve terminals are remodelled. These dynamic processes are likely to be driven by molecular motors. Previously, we have implicated myosins IIA and IIB as opposing motors influencing neuronal growth cone dynamics. Using confocal microscopy of neuromuscular junction preparations colabelled for myosin II isoforms and nerve terminal or muscle endplate markers, we demonstrate that both myosin IIA and myosin IIB are localized in nerve terminals. We propose roles for these motor proteins in junctional stabilization and destabilization.

Original languageEnglish
Pages (from-to)1143-6
Number of pages4
JournalNeuroreport
Volume16
Issue number11
Publication statusPublished - 1 Aug 2005

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Nonmuscle Myosin Type IIB
Nonmuscle Myosin Type IIA
Neuromuscular Junction
Myosin Type II
Muscles
Growth Cones
Cholinergic Receptors
Confocal Microscopy
Protein Isoforms
Proteins

Keywords

  • Animals
  • Bungarotoxins
  • Fluorescent Antibody Technique
  • Mice
  • Mice, Inbred C57BL
  • Microscopy, Confocal
  • Motor Endplate
  • Motor Neurons
  • Neurofilament Proteins
  • Neuromuscular Junction
  • Nonmuscle Myosin Type IIA
  • Nonmuscle Myosin Type IIB
  • Presynaptic Terminals
  • Tubulin

Cite this

Vega-Riveroll, L. J., Wylie, S. R., Loughna, P. T., Parson, S. H., & Chantler, P. D. (2005). Nonmuscle myosins IIA and IIB are present in adult motor nerve terminals. Neuroreport, 16(11), 1143-6.

Nonmuscle myosins IIA and IIB are present in adult motor nerve terminals. / Vega-Riveroll, Laura J; Wylie, Steven R; Loughna, Paul T; Parson, Simon H; Chantler, Peter D.

In: Neuroreport, Vol. 16, No. 11, 01.08.2005, p. 1143-6.

Research output: Contribution to journalArticle

Vega-Riveroll, LJ, Wylie, SR, Loughna, PT, Parson, SH & Chantler, PD 2005, 'Nonmuscle myosins IIA and IIB are present in adult motor nerve terminals', Neuroreport, vol. 16, no. 11, pp. 1143-6.
Vega-Riveroll LJ, Wylie SR, Loughna PT, Parson SH, Chantler PD. Nonmuscle myosins IIA and IIB are present in adult motor nerve terminals. Neuroreport. 2005 Aug 1;16(11):1143-6.
Vega-Riveroll, Laura J ; Wylie, Steven R ; Loughna, Paul T ; Parson, Simon H ; Chantler, Peter D. / Nonmuscle myosins IIA and IIB are present in adult motor nerve terminals. In: Neuroreport. 2005 ; Vol. 16, No. 11. pp. 1143-6.
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