Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: a systematic overview - the SENATOR Project ONTOP Series

Isabel Lozano-Montoya, Andrea Correa-Pérez, Iosief Abraha, Roy L Soiza, Antonio Cherubini, Denis O'Mahony, Alfonso J Cruz-Jentoft

Research output: Contribution to journalReview article

26 Citations (Scopus)
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Abstract

BACKGROUND: Physical frailty (PF) and sarcopenia are predictors of negative health outcomes such as falls, disability, hospitalization, and death. Some systematic reviews (SRs) have been published on different nonpharmacological treatments of frailty and sarcopenia using heterogeneous definitions of them.

OBJECTIVE: To critically appraise the evidence from SRs of the primary studies on nonpharmacological interventions to treat PF (defined by Fried's frailty phenotype) and sarcopenia (defined by the EWGSOP) in older patients.

DESIGN: Overview of SRs and meta-analysis of comparative studies.

DATA SOURCES: PubMed, Cochrane Database of Systematic Reviews, EMBASE, and CINAHL were searched in October 2015.

ELIGIBILITY CRITERIA FOR SELECTING STUDIES: SRs that included at least one comparative study evaluating any nonpharmacological intervention to treat PF or sarcopenia in older patients in any health care setting. Any primary study described in these SRs with experimental design was included.

DATA EXTRACTION AND MANAGEMENT: Two reviewers independently screened titles, abstracts, and full-texts of articles. Quality assessment was carried out by using criteria from the Cochrane Collaboration and the GRADE working group.

RESULTS: Ten SRs with 5 primary studies satisfied the inclusion criteria. The most frequent interventions in the included studies were physical exercise (4) and nutritional supplementation (2). Muscle strength (MS; except for one study in a frail population) and physical performance (PP; except for another study in a frail population) improved with exercise and amino acid supplementation in frail and sarcopenic old adults. Falls and activities of daily living were assessed in two studies with opposite results. The overall quality of the evidence was low.

CONCLUSION: This overview of SRs highlights the importance of exercise interventions with or without nutritional supplementation to improve the PP in community-dwelling patients aged >65 years with PF and sarcopenia. MS improved with multidisciplinary treatment and exercise interventions in this population.

Original languageEnglish
Pages (from-to)721-740
Number of pages20
JournalClinical interventions in aging
Volume12
DOIs
Publication statusPublished - 24 Apr 2017

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Sarcopenia
Exercise
Population
Independent Living
Frail Elderly
Muscle Strength
Activities of Daily Living
PubMed
Meta-Analysis
Hospitalization
Research Design
Databases
Delivery of Health Care
Phenotype
Amino Acids
Health
Therapeutics

Keywords

  • Aged
  • Dietary Supplements
  • Exercise
  • Frail Elderly
  • Humans
  • Muscle Strength
  • Sarcopenia
  • Journal Article
  • Review

Cite this

Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients : a systematic overview - the SENATOR Project ONTOP Series. / Lozano-Montoya, Isabel; Correa-Pérez, Andrea; Abraha, Iosief; Soiza, Roy L; Cherubini, Antonio; O'Mahony, Denis; Cruz-Jentoft, Alfonso J.

In: Clinical interventions in aging, Vol. 12, 24.04.2017, p. 721-740.

Research output: Contribution to journalReview article

Lozano-Montoya, Isabel ; Correa-Pérez, Andrea ; Abraha, Iosief ; Soiza, Roy L ; Cherubini, Antonio ; O'Mahony, Denis ; Cruz-Jentoft, Alfonso J. / Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients : a systematic overview - the SENATOR Project ONTOP Series. In: Clinical interventions in aging. 2017 ; Vol. 12. pp. 721-740.
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abstract = "BACKGROUND: Physical frailty (PF) and sarcopenia are predictors of negative health outcomes such as falls, disability, hospitalization, and death. Some systematic reviews (SRs) have been published on different nonpharmacological treatments of frailty and sarcopenia using heterogeneous definitions of them.OBJECTIVE: To critically appraise the evidence from SRs of the primary studies on nonpharmacological interventions to treat PF (defined by Fried's frailty phenotype) and sarcopenia (defined by the EWGSOP) in older patients.DESIGN: Overview of SRs and meta-analysis of comparative studies.DATA SOURCES: PubMed, Cochrane Database of Systematic Reviews, EMBASE, and CINAHL were searched in October 2015.ELIGIBILITY CRITERIA FOR SELECTING STUDIES: SRs that included at least one comparative study evaluating any nonpharmacological intervention to treat PF or sarcopenia in older patients in any health care setting. Any primary study described in these SRs with experimental design was included.DATA EXTRACTION AND MANAGEMENT: Two reviewers independently screened titles, abstracts, and full-texts of articles. Quality assessment was carried out by using criteria from the Cochrane Collaboration and the GRADE working group.RESULTS: Ten SRs with 5 primary studies satisfied the inclusion criteria. The most frequent interventions in the included studies were physical exercise (4) and nutritional supplementation (2). Muscle strength (MS; except for one study in a frail population) and physical performance (PP; except for another study in a frail population) improved with exercise and amino acid supplementation in frail and sarcopenic old adults. Falls and activities of daily living were assessed in two studies with opposite results. The overall quality of the evidence was low.CONCLUSION: This overview of SRs highlights the importance of exercise interventions with or without nutritional supplementation to improve the PP in community-dwelling patients aged >65 years with PF and sarcopenia. MS improved with multidisciplinary treatment and exercise interventions in this population.",
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T2 - a systematic overview - the SENATOR Project ONTOP Series

AU - Lozano-Montoya, Isabel

AU - Correa-Pérez, Andrea

AU - Abraha, Iosief

AU - Soiza, Roy L

AU - Cherubini, Antonio

AU - O'Mahony, Denis

AU - Cruz-Jentoft, Alfonso J

N1 - The authors thank the following panel members who participated in the Delphi process to identify relevant outcomes: Hubert Blain, Andrea Corsonello, Giuseppina Dell’aquila, Adalsteinn Gudmundsson, Gunnar Akner, Mirko Petrovic, Regina Roller-Wirnsberger, Fabio Salvi, and Fabiana Trotta. The research leading to these results has been funded by the European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement No 305930 (SENATOR).

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N2 - BACKGROUND: Physical frailty (PF) and sarcopenia are predictors of negative health outcomes such as falls, disability, hospitalization, and death. Some systematic reviews (SRs) have been published on different nonpharmacological treatments of frailty and sarcopenia using heterogeneous definitions of them.OBJECTIVE: To critically appraise the evidence from SRs of the primary studies on nonpharmacological interventions to treat PF (defined by Fried's frailty phenotype) and sarcopenia (defined by the EWGSOP) in older patients.DESIGN: Overview of SRs and meta-analysis of comparative studies.DATA SOURCES: PubMed, Cochrane Database of Systematic Reviews, EMBASE, and CINAHL were searched in October 2015.ELIGIBILITY CRITERIA FOR SELECTING STUDIES: SRs that included at least one comparative study evaluating any nonpharmacological intervention to treat PF or sarcopenia in older patients in any health care setting. Any primary study described in these SRs with experimental design was included.DATA EXTRACTION AND MANAGEMENT: Two reviewers independently screened titles, abstracts, and full-texts of articles. Quality assessment was carried out by using criteria from the Cochrane Collaboration and the GRADE working group.RESULTS: Ten SRs with 5 primary studies satisfied the inclusion criteria. The most frequent interventions in the included studies were physical exercise (4) and nutritional supplementation (2). Muscle strength (MS; except for one study in a frail population) and physical performance (PP; except for another study in a frail population) improved with exercise and amino acid supplementation in frail and sarcopenic old adults. Falls and activities of daily living were assessed in two studies with opposite results. The overall quality of the evidence was low.CONCLUSION: This overview of SRs highlights the importance of exercise interventions with or without nutritional supplementation to improve the PP in community-dwelling patients aged >65 years with PF and sarcopenia. MS improved with multidisciplinary treatment and exercise interventions in this population.

AB - BACKGROUND: Physical frailty (PF) and sarcopenia are predictors of negative health outcomes such as falls, disability, hospitalization, and death. Some systematic reviews (SRs) have been published on different nonpharmacological treatments of frailty and sarcopenia using heterogeneous definitions of them.OBJECTIVE: To critically appraise the evidence from SRs of the primary studies on nonpharmacological interventions to treat PF (defined by Fried's frailty phenotype) and sarcopenia (defined by the EWGSOP) in older patients.DESIGN: Overview of SRs and meta-analysis of comparative studies.DATA SOURCES: PubMed, Cochrane Database of Systematic Reviews, EMBASE, and CINAHL were searched in October 2015.ELIGIBILITY CRITERIA FOR SELECTING STUDIES: SRs that included at least one comparative study evaluating any nonpharmacological intervention to treat PF or sarcopenia in older patients in any health care setting. Any primary study described in these SRs with experimental design was included.DATA EXTRACTION AND MANAGEMENT: Two reviewers independently screened titles, abstracts, and full-texts of articles. Quality assessment was carried out by using criteria from the Cochrane Collaboration and the GRADE working group.RESULTS: Ten SRs with 5 primary studies satisfied the inclusion criteria. The most frequent interventions in the included studies were physical exercise (4) and nutritional supplementation (2). Muscle strength (MS; except for one study in a frail population) and physical performance (PP; except for another study in a frail population) improved with exercise and amino acid supplementation in frail and sarcopenic old adults. Falls and activities of daily living were assessed in two studies with opposite results. The overall quality of the evidence was low.CONCLUSION: This overview of SRs highlights the importance of exercise interventions with or without nutritional supplementation to improve the PP in community-dwelling patients aged >65 years with PF and sarcopenia. MS improved with multidisciplinary treatment and exercise interventions in this population.

KW - Aged

KW - Dietary Supplements

KW - Exercise

KW - Frail Elderly

KW - Humans

KW - Muscle Strength

KW - Sarcopenia

KW - Journal Article

KW - Review

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JO - Clinical interventions in aging

JF - Clinical interventions in aging

SN - 1176-9092

ER -