Not so hot: optimal housing temperatures for mice to mimic the thermal environment of humans

John R Speakman, Jaap Keijer

Research output: Contribution to journalArticle

95 Citations (Scopus)
4 Downloads (Pure)

Abstract

It has been argued that mice should be housed at 30 °C to best mimic the thermal conditions experienced by humans, and that the current practice of housing mice at 20-22 °C impairs the suitability of mice as a model for human physiology and disease. In the current paper we challenge this notion. First, we show that humans routinely occupy environments about 3 °C below their lower critical temperature (T lc), which when lightly clothed is about 23 °C. Second, we review the data for the T lc of mice. Mouse T lc is dependent on body weight and about 26-28 °C for adult mice weighing >25 g. The equivalent temperature to that normally experienced by humans for most single housed adult mice is therefore 23-25 °C. Group housing or providing the mice with bedding and nesting material might lower this to about 20-22 °C, close to current standard practice.

Original languageEnglish
Pages (from-to)5-9
Number of pages5
JournalMolecular Metabolism
Volume2
Issue number1
DOIs
Publication statusPublished - Feb 2013

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