Novel aspects of platelet factor XIII function

Joanne L Mitchell, Nicola J Mutch

Research output: Contribution to journalArticle

7 Citations (Scopus)
3 Downloads (Pure)

Abstract

Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed review we discuss recent advances in our understanding of the novel intracellular and extracellular functions of platelet FXIII-A.

Original languageEnglish
Pages (from-to)S17-21
Number of pages5
JournalThrombosis Research
Volume141
Issue numberSuppl 2
Early online date17 May 2016
DOIs
Publication statusPublished - May 2016

Fingerprint

Factor XIII
Blood Platelets
Protein Sorting Signals
Hemostasis
Cytoplasm
Proteins

Keywords

  • factor XIII
  • platelets
  • fibrinolysis
  • α2-antiplasmin
  • fibrin

Cite this

Novel aspects of platelet factor XIII function. / Mitchell, Joanne L; Mutch, Nicola J.

In: Thrombosis Research, Vol. 141, No. Suppl 2, 05.2016, p. S17-21.

Research output: Contribution to journalArticle

Mitchell, Joanne L ; Mutch, Nicola J. / Novel aspects of platelet factor XIII function. In: Thrombosis Research. 2016 ; Vol. 141, No. Suppl 2. pp. S17-21.
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