Novel aspects of platelet factor XIII function

Joanne L Mitchell; Nicola J Mutch

doi:10.1016/S0049-3848(16)30356-5

Novel aspects of platelet factor XIII function

Joanne L Mitchell, Nicola J Mutch

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

18 Downloads (Pure)

Abstract

Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed review we discuss recent advances in our understanding of the novel intracellular and extracellular functions of platelet FXIII-A.

Original language	English
Pages (from-to)	S17-21
Number of pages	5
Journal	Thrombosis Research
Volume	141
Issue number	Suppl 2
Early online date	17 May 2016
DOIs	https://doi.org/10.1016/S0049-3848(16)30356-5
Publication status	Published - May 2016

Keywords

factor XIII
platelets
fibrinolysis
α2-antiplasmin
fibrin

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Accepted Manuscript
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 251 KBLicence: CC BY-NC-ND

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abstract = "Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed review we discuss recent advances in our understanding of the novel intracellular and extracellular functions of platelet FXIII-A.",

keywords = "factor XIII, platelets, fibrinolysis, α2-antiplasmin, fibrin",

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note = "Acknowledgments The study was supported by grants FS/11/2/28579 (N.J.M.) from the British Heart Foundation and the University of Aberdeen Development Trust.",

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AU - Mitchell, Joanne L

AU - Mutch, Nicola J

N1 - Acknowledgments The study was supported by grants FS/11/2/28579 (N.J.M.) from the British Heart Foundation and the University of Aberdeen Development Trust.

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N2 - Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed review we discuss recent advances in our understanding of the novel intracellular and extracellular functions of platelet FXIII-A.

AB - Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed review we discuss recent advances in our understanding of the novel intracellular and extracellular functions of platelet FXIII-A.

KW - factor XIII

KW - platelets

KW - fibrinolysis

KW - α2-antiplasmin

KW - fibrin

U2 - 10.1016/S0049-3848(16)30356-5

DO - 10.1016/S0049-3848(16)30356-5

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SP - S17-21

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

IS - Suppl 2

ER -

Novel aspects of platelet factor XIII function

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