Novel case of takotsubo cardiomyopathy following COVID-19 vaccination

Caitlin Stewart; David T. Gamble; Dana Dawson

doi:10.1136/bcr-2021-247291

Novel case of takotsubo cardiomyopathy following COVID-19 vaccination

Caitlin Stewart, David T. Gamble^*, Dana Dawson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We present an unusual case of takotsubo cardiomyopathy (TTC) following administration of the second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination. This woman in her early 50s presented to the emergency department 8 days following her vaccine with central chest pain. Initial investigations revealed a raised troponin and evolving T wave inversion on ECG. Acute coronary syndrome management was commenced. Further investigations revealed non-obstructive coronary arteries on coronary angiography and imaging revealed hypokinesia of the anterior and anterior-septal walls in the apex and midcavity level, myocardial oedema and no infarction, all in keeping with TTC. Given the large-scale roll out of vaccinations during the COVID-19 pandemic better understanding of potential adverse events is essential. This is the first case report of TTC following a second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination.

Original language	English
Article number	e247291
Number of pages	4
Journal	BMJ Case Reports
Volume	15
Issue number	1
Early online date	18 Jan 2022
DOIs	https://doi.org/10.1136/bcr-2021-247291
Publication status	Published - 18 Jan 2022

Bibliographical note

Acknowledgements Janaki Srinivasan for preparing the echocardiography images used in this report.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

Keywords

Cardiovascular medicine
COVID-19
Healthcare improvement and patient safety

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Novel case of takotsubo cardiomyopathy following COVID-19 vaccination",

abstract = "We present an unusual case of takotsubo cardiomyopathy (TTC) following administration of the second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination. This woman in her early 50s presented to the emergency department 8 days following her vaccine with central chest pain. Initial investigations revealed a raised troponin and evolving T wave inversion on ECG. Acute coronary syndrome management was commenced. Further investigations revealed non-obstructive coronary arteries on coronary angiography and imaging revealed hypokinesia of the anterior and anterior-septal walls in the apex and midcavity level, myocardial oedema and no infarction, all in keeping with TTC. Given the large-scale roll out of vaccinations during the COVID-19 pandemic better understanding of potential adverse events is essential. This is the first case report of TTC following a second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination. ",

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author = "Caitlin Stewart and Gamble, {David T.} and Dana Dawson",

note = "Acknowledgements Janaki Srinivasan for preparing the echocardiography images used in this report. Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.",

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AU - Gamble, David T.

AU - Dawson, Dana

N1 - Acknowledgements Janaki Srinivasan for preparing the echocardiography images used in this report. Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

PY - 2022/1/18

Y1 - 2022/1/18

N2 - We present an unusual case of takotsubo cardiomyopathy (TTC) following administration of the second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination. This woman in her early 50s presented to the emergency department 8 days following her vaccine with central chest pain. Initial investigations revealed a raised troponin and evolving T wave inversion on ECG. Acute coronary syndrome management was commenced. Further investigations revealed non-obstructive coronary arteries on coronary angiography and imaging revealed hypokinesia of the anterior and anterior-septal walls in the apex and midcavity level, myocardial oedema and no infarction, all in keeping with TTC. Given the large-scale roll out of vaccinations during the COVID-19 pandemic better understanding of potential adverse events is essential. This is the first case report of TTC following a second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination.

AB - We present an unusual case of takotsubo cardiomyopathy (TTC) following administration of the second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination. This woman in her early 50s presented to the emergency department 8 days following her vaccine with central chest pain. Initial investigations revealed a raised troponin and evolving T wave inversion on ECG. Acute coronary syndrome management was commenced. Further investigations revealed non-obstructive coronary arteries on coronary angiography and imaging revealed hypokinesia of the anterior and anterior-septal walls in the apex and midcavity level, myocardial oedema and no infarction, all in keeping with TTC. Given the large-scale roll out of vaccinations during the COVID-19 pandemic better understanding of potential adverse events is essential. This is the first case report of TTC following a second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination.

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Novel case of takotsubo cardiomyopathy following COVID-19 vaccination

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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