Novel South African Rare Actinomycete Kribbellaspeibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including New Dehydroxylated Congeners

Kojo Sekyi Acquah, Denzil R Beukes, Digby F Warner, Paul R Meyers, Suthananda N Sunassee, Fleurdeliz Maglangit, Hai Deng, Marcel Jaspars, David W Gammon* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated desferrioxamines, speibonoxamine 1 and desoxy-desferrioxamine D12, have been isolated, together with four known hydroxamates, desferrioxamine D13, desferrioxamine B 4, desoxy-nocardamine 5 and nocardamine 6, and a diketopiperazine (DKP) 7. The structures of 1-7 were characterized by the analysis of HRESIMS and 1D and 2D NMR data, as well as by comparison with the relevant literature. Three new dehydroxy desferrioxamine derivatives 8-10 were tentatively identified in the molecular network of K.speibonae strain SK5 extracts, and structures were proposed based on their MS/MS fragmentation patterns. A plausible spb biosynthetic pathway was proposed. To the best of our knowledge, this is the first report of the isolation of desferrioxamines from the actinobacterial genus Kribbella.

Original languageEnglish
Article number2979
Number of pages12
JournalMolecules
Volume25
Issue number13
DOIs
Publication statusPublished - 29 Jun 2020

Keywords

  • Kribbell
  • Speibonoxamine
  • Siderophore
  • Hydroxamante
  • molecular networking
  • mass spectrometry
  • BIOSYNTHESIS
  • hydroxamate
  • Kribbella
  • speibonoxamine
  • siderophore
  • Molecular networking
  • Hydroxamate
  • Mass spectrometry

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