Novel Synthetic Strategies for the Development of Tryptophan-Proline Chimeras, Useful Tool for Drug Discovery

Barbara De Filippis, Marialuigia Fantacuzzi, Monica Piras, Massimiliano Baldassarre

Research output: Contribution to journalArticle

5 Downloads (Pure)

Abstract

The de novo design of peptides and proteins represents an innovative tool in the early stage of drug research. Over the last thirty years, many studies have been undertaken to develop new strategies of design and synthesis of peptides with specific conformations. Substituted amino acids exhibit significant biological activity, and play an important role in medicinal chemistry. Proline chimeras in particular, are valuable tools for biological investigations. In the literature several strategies for the synthesis of this chimeras are reported. Here we will focus on Tryptophan-Proline and summarize useful methodologies that can be applied to their preparation.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalCurrent Bioactive Compounds
Volume12
Issue number3
Publication statusPublished - Sep 2016

Fingerprint

Drug Discovery
Proline
Tryptophan
Peptides
Pharmaceutical Chemistry
Amino Acids
Research
Pharmaceutical Preparations
Proteins

Keywords

  • Peptide
  • Substituted proline
  • Synthesis
  • Tryptophan-Proline chimeras

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Novel Synthetic Strategies for the Development of Tryptophan-Proline Chimeras, Useful Tool for Drug Discovery. / De Filippis, Barbara; Fantacuzzi, Marialuigia; Piras, Monica; Baldassarre, Massimiliano.

In: Current Bioactive Compounds, Vol. 12, No. 3, 09.2016, p. 161-167.

Research output: Contribution to journalArticle

@article{c9b16e63d870440b995a41248d16e0cf,
title = "Novel Synthetic Strategies for the Development of Tryptophan-Proline Chimeras, Useful Tool for Drug Discovery",
abstract = "The de novo design of peptides and proteins represents an innovative tool in the early stage of drug research. Over the last thirty years, many studies have been undertaken to develop new strategies of design and synthesis of peptides with specific conformations. Substituted amino acids exhibit significant biological activity, and play an important role in medicinal chemistry. Proline chimeras in particular, are valuable tools for biological investigations. In the literature several strategies for the synthesis of this chimeras are reported. Here we will focus on Tryptophan-Proline and summarize useful methodologies that can be applied to their preparation.",
keywords = "Peptide, Substituted proline, Synthesis, Tryptophan-Proline chimeras",
author = "{De Filippis}, Barbara and Marialuigia Fantacuzzi and Monica Piras and Massimiliano Baldassarre",
year = "2016",
month = "9",
language = "English",
volume = "12",
pages = "161--167",
journal = "Current Bioactive Compounds",
issn = "1573-4072",
publisher = "Bentham Science Publishers B.V.",
number = "3",

}

TY - JOUR

T1 - Novel Synthetic Strategies for the Development of Tryptophan-Proline Chimeras, Useful Tool for Drug Discovery

AU - De Filippis, Barbara

AU - Fantacuzzi, Marialuigia

AU - Piras, Monica

AU - Baldassarre, Massimiliano

PY - 2016/9

Y1 - 2016/9

N2 - The de novo design of peptides and proteins represents an innovative tool in the early stage of drug research. Over the last thirty years, many studies have been undertaken to develop new strategies of design and synthesis of peptides with specific conformations. Substituted amino acids exhibit significant biological activity, and play an important role in medicinal chemistry. Proline chimeras in particular, are valuable tools for biological investigations. In the literature several strategies for the synthesis of this chimeras are reported. Here we will focus on Tryptophan-Proline and summarize useful methodologies that can be applied to their preparation.

AB - The de novo design of peptides and proteins represents an innovative tool in the early stage of drug research. Over the last thirty years, many studies have been undertaken to develop new strategies of design and synthesis of peptides with specific conformations. Substituted amino acids exhibit significant biological activity, and play an important role in medicinal chemistry. Proline chimeras in particular, are valuable tools for biological investigations. In the literature several strategies for the synthesis of this chimeras are reported. Here we will focus on Tryptophan-Proline and summarize useful methodologies that can be applied to their preparation.

KW - Peptide

KW - Substituted proline

KW - Synthesis

KW - Tryptophan-Proline chimeras

UR - http://www.scopus.com/inward/record.url?scp=84987754732&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 161

EP - 167

JO - Current Bioactive Compounds

JF - Current Bioactive Compounds

SN - 1573-4072

IS - 3

ER -