Abstract
A novel tetracycline resistance gene, designated tet(32), which confers a high level of tetracycline resistance, was identified in the Clostridium-related human colonic anaerobe K10, which also carries tet(W). tet(32) was transmissible in vitro to the rumen anaerobe Butyrivibrio fibrisolvens 2221(R). The predicted gene product of tet(32) has 76% amino acid identity with Tet(O). PCR amplification indicated that tet(32) is widely distributed in the ovine rumen and in porcine feces.
Original language | English |
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Pages (from-to) | 3246-3249 |
Number of pages | 4 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 45 |
Issue number | 11 |
Publication status | Published - Nov 2001 |
Keywords
- HUMAN GUT
- BACTERIA
- DETERMINANTS
- EXPRESSION
- TET(W)
- DNA