Novel tetracycline resistance gene, tet(32), in the Clostridium-related human colonic anaerobe K10 and its transmission in vitro to the rumen anaerobe Butyrivibrio fibrisolvens

C M Melville, K P Scott, D K Mercer, H J Flint

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47 Citations (Scopus)

Abstract

A novel tetracycline resistance gene, designated tet(32), which confers a high level of tetracycline resistance, was identified in the Clostridium-related human colonic anaerobe K10, which also carries tet(W). tet(32) was transmissible in vitro to the rumen anaerobe Butyrivibrio fibrisolvens 2221(R). The predicted gene product of tet(32) has 76% amino acid identity with Tet(O). PCR amplification indicated that tet(32) is widely distributed in the ovine rumen and in porcine feces.

Original languageEnglish
Pages (from-to)3246-3249
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number11
Publication statusPublished - Nov 2001

Keywords

  • HUMAN GUT
  • BACTERIA
  • DETERMINANTS
  • EXPRESSION
  • TET(W)
  • DNA

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