Nuclear hormone receptor architecture - form and dynamics

Iain J McEwan, Ann M Nardulli

Research output: Contribution to conferencePaper

7 Citations (Scopus)

Abstract

Nuclear hormone receptors (NHRs) represent a large and diverse family of ligand-activated transcription factors involved in regulating development, metabolic homeostasis, salt balance and reproductive health. The ligands for these receptors are typically small hydrophobic molecules such as steroid hormones, thyroid hormone, vitamin D3 and fatty acid derivatives. The first NHR structural information appeared ~20 years ago with the solution and crystal structures of the DNA binding domains and was followed by the structure of the agonist and antagonist bound ligand binding domains of different NHR members. Interestingly, in addition to these defined structural features, it has become clear that NHRs also possess significant structural plasticity. Thus, the dynamic structure of the NHRs was the topic of a recent stimulating and informative FASEB Summer Research Conference held in Vermont.
Original languageEnglish
Pagese011
DOIs
Publication statusPublished - 31 Dec 2009
Event2009 FASEB Summer Conference on Dynamic Structure of the Nuclear Hormone Receptors - Vermont, United Kingdom
Duration: 9 Aug 200914 Aug 2009

Conference

Conference2009 FASEB Summer Conference on Dynamic Structure of the Nuclear Hormone Receptors
CountryUnited Kingdom
CityVermont
Period9/08/0914/08/09

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McEwan, I. J., & Nardulli, A. M. (2009). Nuclear hormone receptor architecture - form and dynamics. e011. Paper presented at 2009 FASEB Summer Conference on Dynamic Structure of the Nuclear Hormone Receptors, Vermont, United Kingdom. https://doi.org/10.1621/nrs.07011