Nuclear Receptors

From Structure to the Clinic

Iain J. McEwan* (Editor), Raj Kumar (Editor)

*Corresponding author for this work

Research output: Book/ReportBook

Abstract

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.

Original languageEnglish
PublisherSpringer International Publishing
Number of pages236
ISBN (Electronic)9783319187297
ISBN (Print)9783319187280
DOIs
Publication statusPublished - 2015

Fingerprint

Cytoplasmic and Nuclear Receptors
Steroid hormones
Ligands
Hormones
Proteins
Metabolism
Allosteric Regulation
Steroid Receptors
Cloning
Immune system
Physiology
Response Elements
Structural analysis
Vitamins
Reproduction
Conformations
Organism Cloning
Immune System
Brain
Transcription Factors

Keywords

  • NMR spectroscopy
  • glucocorticoids
  • ligands
  • nuclear receptors
  • protein interactions
  • selective androgen receptor modulators
  • selective estrogen receptor modulators
  • steroid hormones

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nuclear Receptors : From Structure to the Clinic. / McEwan, Iain J. (Editor); Kumar, Raj (Editor).

Springer International Publishing, 2015. 236 p.

Research output: Book/ReportBook

McEwan, Iain J. (Editor) ; Kumar, Raj (Editor). / Nuclear Receptors : From Structure to the Clinic. Springer International Publishing, 2015. 236 p.
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