Nucleus accumbens and delay discounting in rats: evidence from a new quantitative protocol for analysing inter-temporal choice

L Valencia-Torres, C M Olarte Sanchez, S da Costa Araújo, S Body, C M Bradshaw, E Szabadi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Rationale
There is evidence that the core of the nucleus accumbens (AcbC) is involved in inter-temporal choice behaviour.
Objective
A new behavioural protocol was used to examine the effect of destruction of the AcbC on delay discounting in inter-temporal choice schedules in rats.
Method
Rats with excitotoxic lesions of the AcbC or sham lesions made repeated choices on an adjusting-delay schedule between a smaller reinforcer (A) that was delivered immediately and a larger reinforcer (B) that was delivered after a delay which increased or decreased depending on the subject’s choices. In two phases of the experiment, reinforcer sizes were selected which enabled theoretical parameters expressing delay discounting and sensitivity to reinforcer size to be estimated from the ratio of the indifference delays (i.e. the quasi-stable values of the adjusting delay seen after extended training) obtained in the two phases.
Results
In both groups, indifference delays were shorter when the sizes of A and B were 14 and 25 μl than when they were 25 and 100 μl of a 0.6 M sucrose solution. Indifference delays were shorter in AcbC-lesioned than in sham-lesioned rats. Estimates of delay discounting rate based on the ratio of the indifference delays were lower in the AcbC-lesioned than in the sham-lesioned rats. The size sensitivity parameter did not differ between the groups. Adjusting delays in successive blocks of trials were analysed using Fourier transform. The period corresponding to the dominant frequency of the power spectrum and power within the dominant frequency band did not differ between the groups.
Conclusions
Destruction of the AcbC increased the rate of delay discounting.
Original languageEnglish
Pages (from-to)271-283
Number of pages13
JournalPsychopharmacology
Volume219
Issue number2
Early online date6 Sep 2011
DOIs
Publication statusPublished - Jan 2012

Fingerprint

Nucleus Accumbens
Appointments and Schedules
Choice Behavior
Fourier Analysis
Sucrose
Delay Discounting

Keywords

  • animals
  • choice behavior
  • conditioning, operant
  • female
  • impulsive behavior
  • microinjections
  • models, psychological
  • nucleus accumbens
  • quinolinic acid
  • rats
  • rats, wistar
  • reinforcement (psychology)
  • reinforcement schedule
  • time factors

Cite this

Valencia-Torres, L., Olarte Sanchez, C. M., da Costa Araújo, S., Body, S., Bradshaw, C. M., & Szabadi, E. (2012). Nucleus accumbens and delay discounting in rats: evidence from a new quantitative protocol for analysing inter-temporal choice. Psychopharmacology, 219(2), 271-283. https://doi.org/10.1007/s00213-011-2459-1

Nucleus accumbens and delay discounting in rats : evidence from a new quantitative protocol for analysing inter-temporal choice. / Valencia-Torres, L; Olarte Sanchez, C M; da Costa Araújo, S; Body, S; Bradshaw, C M; Szabadi, E.

In: Psychopharmacology, Vol. 219, No. 2, 01.2012, p. 271-283.

Research output: Contribution to journalArticle

Valencia-Torres, L, Olarte Sanchez, CM, da Costa Araújo, S, Body, S, Bradshaw, CM & Szabadi, E 2012, 'Nucleus accumbens and delay discounting in rats: evidence from a new quantitative protocol for analysing inter-temporal choice', Psychopharmacology, vol. 219, no. 2, pp. 271-283. https://doi.org/10.1007/s00213-011-2459-1
Valencia-Torres, L ; Olarte Sanchez, C M ; da Costa Araújo, S ; Body, S ; Bradshaw, C M ; Szabadi, E. / Nucleus accumbens and delay discounting in rats : evidence from a new quantitative protocol for analysing inter-temporal choice. In: Psychopharmacology. 2012 ; Vol. 219, No. 2. pp. 271-283.
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abstract = "RationaleThere is evidence that the core of the nucleus accumbens (AcbC) is involved in inter-temporal choice behaviour.ObjectiveA new behavioural protocol was used to examine the effect of destruction of the AcbC on delay discounting in inter-temporal choice schedules in rats.MethodRats with excitotoxic lesions of the AcbC or sham lesions made repeated choices on an adjusting-delay schedule between a smaller reinforcer (A) that was delivered immediately and a larger reinforcer (B) that was delivered after a delay which increased or decreased depending on the subject’s choices. In two phases of the experiment, reinforcer sizes were selected which enabled theoretical parameters expressing delay discounting and sensitivity to reinforcer size to be estimated from the ratio of the indifference delays (i.e. the quasi-stable values of the adjusting delay seen after extended training) obtained in the two phases.ResultsIn both groups, indifference delays were shorter when the sizes of A and B were 14 and 25 μl than when they were 25 and 100 μl of a 0.6 M sucrose solution. Indifference delays were shorter in AcbC-lesioned than in sham-lesioned rats. Estimates of delay discounting rate based on the ratio of the indifference delays were lower in the AcbC-lesioned than in the sham-lesioned rats. The size sensitivity parameter did not differ between the groups. Adjusting delays in successive blocks of trials were analysed using Fourier transform. The period corresponding to the dominant frequency of the power spectrum and power within the dominant frequency band did not differ between the groups.ConclusionsDestruction of the AcbC increased the rate of delay discounting.",
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AU - Olarte Sanchez, C M

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AU - Body, S

AU - Bradshaw, C M

AU - Szabadi, E

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N2 - RationaleThere is evidence that the core of the nucleus accumbens (AcbC) is involved in inter-temporal choice behaviour.ObjectiveA new behavioural protocol was used to examine the effect of destruction of the AcbC on delay discounting in inter-temporal choice schedules in rats.MethodRats with excitotoxic lesions of the AcbC or sham lesions made repeated choices on an adjusting-delay schedule between a smaller reinforcer (A) that was delivered immediately and a larger reinforcer (B) that was delivered after a delay which increased or decreased depending on the subject’s choices. In two phases of the experiment, reinforcer sizes were selected which enabled theoretical parameters expressing delay discounting and sensitivity to reinforcer size to be estimated from the ratio of the indifference delays (i.e. the quasi-stable values of the adjusting delay seen after extended training) obtained in the two phases.ResultsIn both groups, indifference delays were shorter when the sizes of A and B were 14 and 25 μl than when they were 25 and 100 μl of a 0.6 M sucrose solution. Indifference delays were shorter in AcbC-lesioned than in sham-lesioned rats. Estimates of delay discounting rate based on the ratio of the indifference delays were lower in the AcbC-lesioned than in the sham-lesioned rats. The size sensitivity parameter did not differ between the groups. Adjusting delays in successive blocks of trials were analysed using Fourier transform. The period corresponding to the dominant frequency of the power spectrum and power within the dominant frequency band did not differ between the groups.ConclusionsDestruction of the AcbC increased the rate of delay discounting.

AB - RationaleThere is evidence that the core of the nucleus accumbens (AcbC) is involved in inter-temporal choice behaviour.ObjectiveA new behavioural protocol was used to examine the effect of destruction of the AcbC on delay discounting in inter-temporal choice schedules in rats.MethodRats with excitotoxic lesions of the AcbC or sham lesions made repeated choices on an adjusting-delay schedule between a smaller reinforcer (A) that was delivered immediately and a larger reinforcer (B) that was delivered after a delay which increased or decreased depending on the subject’s choices. In two phases of the experiment, reinforcer sizes were selected which enabled theoretical parameters expressing delay discounting and sensitivity to reinforcer size to be estimated from the ratio of the indifference delays (i.e. the quasi-stable values of the adjusting delay seen after extended training) obtained in the two phases.ResultsIn both groups, indifference delays were shorter when the sizes of A and B were 14 and 25 μl than when they were 25 and 100 μl of a 0.6 M sucrose solution. Indifference delays were shorter in AcbC-lesioned than in sham-lesioned rats. Estimates of delay discounting rate based on the ratio of the indifference delays were lower in the AcbC-lesioned than in the sham-lesioned rats. The size sensitivity parameter did not differ between the groups. Adjusting delays in successive blocks of trials were analysed using Fourier transform. The period corresponding to the dominant frequency of the power spectrum and power within the dominant frequency band did not differ between the groups.ConclusionsDestruction of the AcbC increased the rate of delay discounting.

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KW - female

KW - impulsive behavior

KW - microinjections

KW - models, psychological

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KW - quinolinic acid

KW - rats

KW - rats, wistar

KW - reinforcement (psychology)

KW - reinforcement schedule

KW - time factors

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JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

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