Numerical Simulation of Convection Enhanced Delivery of Nano Drug Carriers into Brain Tumour

Wenbo Zhan, Ferdinando Rodriguez y Baena

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Convection enhanced delivery (CED) is a promising alternative to systemic administration for bypassing the blood brain barrier, because of which most anticancer drugs are blocked in the blood circulatory system instead of concentrating in the targeted tumour tissue. As drugs are injected directly into the tumour extracellular space during CED treatment, fast drug elimination
due to physical degradation and metabolism significantly hinders effective drug penetration into large tumours, which represents one of the main limitations of CED. If drugs are encapsulated within nanoparticles which are harder for the body to eliminate, drugs can be released in a more controllable manner over time, thereby improving the potential for treatment. The present study aims to examine the impact of tumour and nanoparticle transport properties on the delivery outcomes, with the aim to optimise this drug delivery system.
Original languageEnglish
Title of host publicationBioMedEng18
Subtitle of host publicationConference Proceedings
PublisherBioMedEng
Pages348
Number of pages1
ISBN (Print)978-1-9996465-0-9
Publication statusPublished - 2018

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    Zhan, W., & Baena, F. R. Y. (2018). Numerical Simulation of Convection Enhanced Delivery of Nano Drug Carriers into Brain Tumour. In BioMedEng18: Conference Proceedings (pp. 348). BioMedEng.