Nutritional status and subsequent all-cause mortality in men and women aged 75 years or over living in the community

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Abstract

We prospectively investigated relationships between blood markers of Fe, vitamin B-12, folate, vitamin C and vitamin D status and subsequent allcause mortality in 208 men and 191 women aged 75 years or over living in the community in Aberdeen, Scotland. The participants had been recruited for a cross-sectional study in 1999-2000 when them completed health and lifestyle questionnaires and had blood samples taken for analysis of serum ferritin, serum vitamin 1312, erythrocyte folate, plasma vitamin C and serum 25-hydroxycholecalciferol. Mortality was ascertained on national databases up to December 2005, with a median time of follow up of 69.2 (range 1.0-79-9) months. Participants were divided into sexspecific quintiles of baseline levels for each nutrient, and hazard ratios were estimated with Cox proportional hazard models adjusted for age and sex with the significance of linear trends in the associations assessed by logistic regression. There was no significant association between blood markers of Fe, vitamin B-12 or folate status at baseline and mortality, but vitamin D status at baseline was inversely related to mortality (P for trend < 0.00 1). For vitamin C there was no evidence of a linear trend but participants in the lowest quintile of plasma levels had a significantly higher risk of death than those in the highest quintile. Randomized controlled trials of lifestyle changes which improve vitamin status are needed to assess whether these associations could be causal.

Original languageEnglish
Pages (from-to)593-599
Number of pages7
JournalBritish Journal of Nutrition
Volume98
Issue number3
Early online date19 Apr 2007
DOIs
Publication statusPublished - Sep 2007

Keywords

  • nutritional status
  • vitamin D
  • vitamin C
  • iron
  • mortality
  • elderly
  • vitamin-D
  • ascorbic-acid
  • risk
  • population
  • disease
  • cancer
  • cohort
  • trial

Cite this

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title = "Nutritional status and subsequent all-cause mortality in men and women aged 75 years or over living in the community",
abstract = "We prospectively investigated relationships between blood markers of Fe, vitamin B-12, folate, vitamin C and vitamin D status and subsequent allcause mortality in 208 men and 191 women aged 75 years or over living in the community in Aberdeen, Scotland. The participants had been recruited for a cross-sectional study in 1999-2000 when them completed health and lifestyle questionnaires and had blood samples taken for analysis of serum ferritin, serum vitamin 1312, erythrocyte folate, plasma vitamin C and serum 25-hydroxycholecalciferol. Mortality was ascertained on national databases up to December 2005, with a median time of follow up of 69.2 (range 1.0-79-9) months. Participants were divided into sexspecific quintiles of baseline levels for each nutrient, and hazard ratios were estimated with Cox proportional hazard models adjusted for age and sex with the significance of linear trends in the associations assessed by logistic regression. There was no significant association between blood markers of Fe, vitamin B-12 or folate status at baseline and mortality, but vitamin D status at baseline was inversely related to mortality (P for trend < 0.00 1). For vitamin C there was no evidence of a linear trend but participants in the lowest quintile of plasma levels had a significantly higher risk of death than those in the highest quintile. Randomized controlled trials of lifestyle changes which improve vitamin status are needed to assess whether these associations could be causal.",
keywords = "nutritional status, vitamin D, vitamin C, iron, mortality, elderly, vitamin-D, ascorbic-acid, risk, population, disease, cancer, cohort, trial",
author = "Xueli Jia and Aucott, {Lorna S.} and Geraldine McNeill",
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N2 - We prospectively investigated relationships between blood markers of Fe, vitamin B-12, folate, vitamin C and vitamin D status and subsequent allcause mortality in 208 men and 191 women aged 75 years or over living in the community in Aberdeen, Scotland. The participants had been recruited for a cross-sectional study in 1999-2000 when them completed health and lifestyle questionnaires and had blood samples taken for analysis of serum ferritin, serum vitamin 1312, erythrocyte folate, plasma vitamin C and serum 25-hydroxycholecalciferol. Mortality was ascertained on national databases up to December 2005, with a median time of follow up of 69.2 (range 1.0-79-9) months. Participants were divided into sexspecific quintiles of baseline levels for each nutrient, and hazard ratios were estimated with Cox proportional hazard models adjusted for age and sex with the significance of linear trends in the associations assessed by logistic regression. There was no significant association between blood markers of Fe, vitamin B-12 or folate status at baseline and mortality, but vitamin D status at baseline was inversely related to mortality (P for trend < 0.00 1). For vitamin C there was no evidence of a linear trend but participants in the lowest quintile of plasma levels had a significantly higher risk of death than those in the highest quintile. Randomized controlled trials of lifestyle changes which improve vitamin status are needed to assess whether these associations could be causal.

AB - We prospectively investigated relationships between blood markers of Fe, vitamin B-12, folate, vitamin C and vitamin D status and subsequent allcause mortality in 208 men and 191 women aged 75 years or over living in the community in Aberdeen, Scotland. The participants had been recruited for a cross-sectional study in 1999-2000 when them completed health and lifestyle questionnaires and had blood samples taken for analysis of serum ferritin, serum vitamin 1312, erythrocyte folate, plasma vitamin C and serum 25-hydroxycholecalciferol. Mortality was ascertained on national databases up to December 2005, with a median time of follow up of 69.2 (range 1.0-79-9) months. Participants were divided into sexspecific quintiles of baseline levels for each nutrient, and hazard ratios were estimated with Cox proportional hazard models adjusted for age and sex with the significance of linear trends in the associations assessed by logistic regression. There was no significant association between blood markers of Fe, vitamin B-12 or folate status at baseline and mortality, but vitamin D status at baseline was inversely related to mortality (P for trend < 0.00 1). For vitamin C there was no evidence of a linear trend but participants in the lowest quintile of plasma levels had a significantly higher risk of death than those in the highest quintile. Randomized controlled trials of lifestyle changes which improve vitamin status are needed to assess whether these associations could be causal.

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