Oats and CVD risk markers

a systematic literature review

Frank Thies, Lindsey F Masson, Paolo Boffetta, Penny Kris-Etherton

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

High consumption of whole-grain food such as oats is associated with a reduced risk of CVD and type 2 diabetes. The present study aimed to systematically review the literature describing long-term intervention studies that investigated the effects of oats or oat bran on CVD risk factors. The literature search was conducted using Embase, Medline and the Cochrane library, which identified 654 potential articles. Seventy-six articles describing sixty-nine studies met the inclusion criteria. Most studies lacked statistical power to detect a significant effect of oats on any of the risk factors considered: 59 % of studies had less than thirty subjects in the oat intervention group. Out of sixty-four studies that assessed systemic lipid markers, thirty-seven (58 %) and thirty-four (49 %) showed a significant reduction in total cholesterol (2-19 % reduction) and LDL-cholesterol (4-23 % reduction) respectively, mostly in hypercholesterolaemic subjects. Few studies (three and five, respectively) described significant effects on HDL-cholesterol and TAG concentrations. Only three out of twenty-five studies found a reduction in blood pressure after oat consumption. None of the few studies that measured markers of insulin sensitivity and inflammation found any effect after long-term oat consumption. Long-term dietary intake of oats or oat bran has a beneficial effect on blood cholesterol. However, there is no evidence that it favourably modulates insulin sensitivity. It is still unclear whether increased oat consumption significantly affects other risk markers for CVD risk, and comprehensive, adequately powered and controlled intervention trials are required to address this question.

Original languageEnglish
Pages (from-to)19-30
Number of pages12
JournalBritish Journal of Nutrition
Volume112
Issue numberSuppl 2
Early online date30 Sep 2014
DOIs
Publication statusPublished - Oct 2014

Fingerprint

Insulin Resistance
Cholesterol
Avena
LDL Cholesterol
Type 2 Diabetes Mellitus
HDL Cholesterol
Libraries
Blood Pressure
Inflammation
Lipids
Food
Whole Grains

Keywords

  • Avena
  • Blood Pressure
  • Cardiovascular Diseases
  • Diet
  • Dietary Fiber
  • Edible Grain
  • Humans
  • Lipids
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Cite this

Oats and CVD risk markers : a systematic literature review. / Thies, Frank; Masson, Lindsey F; Boffetta, Paolo; Kris-Etherton, Penny.

In: British Journal of Nutrition, Vol. 112, No. Suppl 2, 10.2014, p. 19-30.

Research output: Contribution to journalArticle

Thies, F, Masson, LF, Boffetta, P & Kris-Etherton, P 2014, 'Oats and CVD risk markers: a systematic literature review', British Journal of Nutrition, vol. 112, no. Suppl 2, pp. 19-30. https://doi.org/10.1017/S0007114514002281
Thies, Frank ; Masson, Lindsey F ; Boffetta, Paolo ; Kris-Etherton, Penny. / Oats and CVD risk markers : a systematic literature review. In: British Journal of Nutrition. 2014 ; Vol. 112, No. Suppl 2. pp. 19-30.
@article{7bfd8d18f8c944cba9e59ceff65c18df,
title = "Oats and CVD risk markers: a systematic literature review",
abstract = "High consumption of whole-grain food such as oats is associated with a reduced risk of CVD and type 2 diabetes. The present study aimed to systematically review the literature describing long-term intervention studies that investigated the effects of oats or oat bran on CVD risk factors. The literature search was conducted using Embase, Medline and the Cochrane library, which identified 654 potential articles. Seventy-six articles describing sixty-nine studies met the inclusion criteria. Most studies lacked statistical power to detect a significant effect of oats on any of the risk factors considered: 59 {\%} of studies had less than thirty subjects in the oat intervention group. Out of sixty-four studies that assessed systemic lipid markers, thirty-seven (58 {\%}) and thirty-four (49 {\%}) showed a significant reduction in total cholesterol (2-19 {\%} reduction) and LDL-cholesterol (4-23 {\%} reduction) respectively, mostly in hypercholesterolaemic subjects. Few studies (three and five, respectively) described significant effects on HDL-cholesterol and TAG concentrations. Only three out of twenty-five studies found a reduction in blood pressure after oat consumption. None of the few studies that measured markers of insulin sensitivity and inflammation found any effect after long-term oat consumption. Long-term dietary intake of oats or oat bran has a beneficial effect on blood cholesterol. However, there is no evidence that it favourably modulates insulin sensitivity. It is still unclear whether increased oat consumption significantly affects other risk markers for CVD risk, and comprehensive, adequately powered and controlled intervention trials are required to address this question.",
keywords = "Avena, Blood Pressure, Cardiovascular Diseases, Diet, Dietary Fiber, Edible Grain, Humans, Lipids, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Frank Thies and Masson, {Lindsey F} and Paolo Boffetta and Penny Kris-Etherton",
note = "Acknowledgements The authors thank M. Mowett for sourcing the majority of the articles. F. T. reviewed articles for inclusion and drafted the paper. L. F. M. carried out the literature search, extracted the data and contributed to writing the paper, P. B. and P. K.-E. contributed to writing the paper. F. T., P. K.-E. and P. B. received an honorarium from Quaker Oats Company (a subsidiary of PepsiCo) for attending the workshop in May 2012 to discuss the content of the supplement and the University of Aberdeen received an unrestricted grant from Quaker Oats Company. L. F. M. has no conflict of interest to report. This paper was published as part of a supplement to British Journal of Nutrition, publication of which was supported by an unrestricted educational grant from Quaker Oats Co. (a subsidiary of PepsiCo Inc.). The papers included in this supplement were invited by the Guest Editor and have undergone the standard journal formal review process. They may be cited.",
year = "2014",
month = "10",
doi = "10.1017/S0007114514002281",
language = "English",
volume = "112",
pages = "19--30",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge Univ. Press.",
number = "Suppl 2",

}

TY - JOUR

T1 - Oats and CVD risk markers

T2 - a systematic literature review

AU - Thies, Frank

AU - Masson, Lindsey F

AU - Boffetta, Paolo

AU - Kris-Etherton, Penny

N1 - Acknowledgements The authors thank M. Mowett for sourcing the majority of the articles. F. T. reviewed articles for inclusion and drafted the paper. L. F. M. carried out the literature search, extracted the data and contributed to writing the paper, P. B. and P. K.-E. contributed to writing the paper. F. T., P. K.-E. and P. B. received an honorarium from Quaker Oats Company (a subsidiary of PepsiCo) for attending the workshop in May 2012 to discuss the content of the supplement and the University of Aberdeen received an unrestricted grant from Quaker Oats Company. L. F. M. has no conflict of interest to report. This paper was published as part of a supplement to British Journal of Nutrition, publication of which was supported by an unrestricted educational grant from Quaker Oats Co. (a subsidiary of PepsiCo Inc.). The papers included in this supplement were invited by the Guest Editor and have undergone the standard journal formal review process. They may be cited.

PY - 2014/10

Y1 - 2014/10

N2 - High consumption of whole-grain food such as oats is associated with a reduced risk of CVD and type 2 diabetes. The present study aimed to systematically review the literature describing long-term intervention studies that investigated the effects of oats or oat bran on CVD risk factors. The literature search was conducted using Embase, Medline and the Cochrane library, which identified 654 potential articles. Seventy-six articles describing sixty-nine studies met the inclusion criteria. Most studies lacked statistical power to detect a significant effect of oats on any of the risk factors considered: 59 % of studies had less than thirty subjects in the oat intervention group. Out of sixty-four studies that assessed systemic lipid markers, thirty-seven (58 %) and thirty-four (49 %) showed a significant reduction in total cholesterol (2-19 % reduction) and LDL-cholesterol (4-23 % reduction) respectively, mostly in hypercholesterolaemic subjects. Few studies (three and five, respectively) described significant effects on HDL-cholesterol and TAG concentrations. Only three out of twenty-five studies found a reduction in blood pressure after oat consumption. None of the few studies that measured markers of insulin sensitivity and inflammation found any effect after long-term oat consumption. Long-term dietary intake of oats or oat bran has a beneficial effect on blood cholesterol. However, there is no evidence that it favourably modulates insulin sensitivity. It is still unclear whether increased oat consumption significantly affects other risk markers for CVD risk, and comprehensive, adequately powered and controlled intervention trials are required to address this question.

AB - High consumption of whole-grain food such as oats is associated with a reduced risk of CVD and type 2 diabetes. The present study aimed to systematically review the literature describing long-term intervention studies that investigated the effects of oats or oat bran on CVD risk factors. The literature search was conducted using Embase, Medline and the Cochrane library, which identified 654 potential articles. Seventy-six articles describing sixty-nine studies met the inclusion criteria. Most studies lacked statistical power to detect a significant effect of oats on any of the risk factors considered: 59 % of studies had less than thirty subjects in the oat intervention group. Out of sixty-four studies that assessed systemic lipid markers, thirty-seven (58 %) and thirty-four (49 %) showed a significant reduction in total cholesterol (2-19 % reduction) and LDL-cholesterol (4-23 % reduction) respectively, mostly in hypercholesterolaemic subjects. Few studies (three and five, respectively) described significant effects on HDL-cholesterol and TAG concentrations. Only three out of twenty-five studies found a reduction in blood pressure after oat consumption. None of the few studies that measured markers of insulin sensitivity and inflammation found any effect after long-term oat consumption. Long-term dietary intake of oats or oat bran has a beneficial effect on blood cholesterol. However, there is no evidence that it favourably modulates insulin sensitivity. It is still unclear whether increased oat consumption significantly affects other risk markers for CVD risk, and comprehensive, adequately powered and controlled intervention trials are required to address this question.

KW - Avena

KW - Blood Pressure

KW - Cardiovascular Diseases

KW - Diet

KW - Dietary Fiber

KW - Edible Grain

KW - Humans

KW - Lipids

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1017/S0007114514002281

DO - 10.1017/S0007114514002281

M3 - Article

VL - 112

SP - 19

EP - 30

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - Suppl 2

ER -