Observational study of current use of selective decontamination of the digestive tract in UK critical care units

R. R. Canter, S. E Harvey (Corresponding Author), D. A. Harrison, M. K. Campbell, K. M Rowan, B. H. Cuthbertson, Selective Decontamination of the Digestive tract in critically ill patients treated in Intensive Care Unit (SuDDICU) Investigators

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Evidence supporting selective decontamination of the digestive tract (SDD) is reasonably strong. We set out to determine use in UK critical care units and to compare patient outcomes between units that do and those that do not use SDD. A total of 250 UK general critical care units were surveyed. Case mix, outcomes, and lengths of stay for admissions to SDD units (with and without an i.v. component) and non-SDD units were compared using data from the Intensive Care National Audit & Research Centre Case Mix Programme database. A response was received from all the 250 critical care units surveyed. Of these, 13 (5.2%) reported using SDD on some or all admissions, and of these, 3 reported using an i.v. component. Data on 284,690 admissions (April 2008-March 2011) from units reporting to the ICNARC Case Mix Programme (CMP) were included in the analyses. Admissions to SDD (n=196) and non-SDD (n=9) units were a similar case mix with similar infection rates and average lengths of stay in the unit and hospital. There was no difference in risk-adjusted unit or hospital mortality. The rate of unit-acquired infections in blood was significantly lower in SDD units using an i.v. component. Use of SDD in UK critical care is very low. The rate of unit-acquired infections in blood was significantly lower in SDD units using an i.v. component, but did not translate into a difference in acute hospital mortality or length of stay. There is a need to better understand the barriers to adoption of SDD into clinical practice and such work is underway.

Original languageEnglish
Pages (from-to)610-617
Number of pages8
JournalBritish Journal of Anaesthesia
Volume113
Issue number4
Early online date14 May 2014
DOIs
Publication statusPublished - Oct 2014

Fingerprint

Decontamination
Critical Care
Observational Studies
Gastrointestinal Tract
Diagnosis-Related Groups
Length of Stay
Hospital Mortality
Infection
Hospital Units
Databases

Keywords

  • antibacterial agents
  • critical care
  • epidemiology
  • infection

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Canter, R. R., Harvey, S. E., Harrison, D. A., Campbell, M. K., M Rowan, K., Cuthbertson, B. H., & Selective Decontamination of the Digestive tract in critically ill patients treated in Intensive Care Unit (SuDDICU) Investigators (2014). Observational study of current use of selective decontamination of the digestive tract in UK critical care units. British Journal of Anaesthesia, 113(4), 610-617. https://doi.org/10.1093/bja/aeu108

Observational study of current use of selective decontamination of the digestive tract in UK critical care units. / Canter, R. R.; Harvey, S. E (Corresponding Author); Harrison, D. A.; Campbell, M. K.; M Rowan, K.; Cuthbertson, B. H.; Selective Decontamination of the Digestive tract in critically ill patients treated in Intensive Care Unit (SuDDICU) Investigators.

In: British Journal of Anaesthesia, Vol. 113, No. 4, 10.2014, p. 610-617.

Research output: Contribution to journalArticle

Canter, RR, Harvey, SE, Harrison, DA, Campbell, MK, M Rowan, K, Cuthbertson, BH & Selective Decontamination of the Digestive tract in critically ill patients treated in Intensive Care Unit (SuDDICU) Investigators 2014, 'Observational study of current use of selective decontamination of the digestive tract in UK critical care units' British Journal of Anaesthesia, vol. 113, no. 4, pp. 610-617. https://doi.org/10.1093/bja/aeu108
Canter, R. R. ; Harvey, S. E ; Harrison, D. A. ; Campbell, M. K. ; M Rowan, K. ; Cuthbertson, B. H. ; Selective Decontamination of the Digestive tract in critically ill patients treated in Intensive Care Unit (SuDDICU) Investigators. / Observational study of current use of selective decontamination of the digestive tract in UK critical care units. In: British Journal of Anaesthesia. 2014 ; Vol. 113, No. 4. pp. 610-617.
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